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    Shal Shaker cognate l [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40129, updated on 10-May-2024

    Summary

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    Official Symbol
    Shalprovided by FlyBase
    Official Full Name
    Shaker cognate lprovided by FlyBase
    Primary source
    FLYBASE:FBgn0005564
    Locus tag
    Dmel_CG9262
    See related
    AllianceGenome:FB:FBgn0005564
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9262; Dmel\CG9262; DNK[[v]]4; dShal; Kv4; Kv4/Shal; K[[v]]4; Sh-l; shaI; ShaI; shal; Shl
    Summary
    Enables A-type (transient outward) potassium channel activity. Involved in associative learning and chemical synaptic transmission. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be integral component of membrane. Is expressed in adult head; embryonic/larval muscle system; embryonic/larval nervous system; presumptive embryonic/larval system; and ventral midline of embryo. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to several human genes including KCND3 (potassium voltage-gated channel subfamily D member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    76B7-76B8; 3-45 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19566851..19584568, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19559951..19577668, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44676 Neighboring gene long non-coding RNA:CR45916 Neighboring gene mir-9a stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Down-Regulation of K(V)4 Channel in Drosophila Mushroom Body Neurons Contributes to Aβ42-Induced Courtship Memory Deficits. Feng G, et al. Neuroscience, 2018 Feb 1. PMID 28627422
    2. Mapping the function of neuronal ion channels in model and experiment. Podlaski WF, et al. Elife, 2017 Mar 6. PMID 28267430, Free PMC Article
    3. Segmental differences in firing properties and potassium currents in Drosophila larval motoneurons. Srinivasan S, et al. J Neurophysiol, 2012 Mar. PMID 22157123, Free PMC Article
    4. Role of intrinsic properties in Drosophila motoneuron recruitment during fictive crawling. Schaefer JE, et al. J Neurophysiol, 2010 Sep. PMID 20573969, Free PMC Article
    5. Age-related changes in Kv4/Shal and Kv1/Shaker expression in Drosophila and a role for reactive oxygen species. Vallejos MJ, et al. PLoS One, 2021. PMID 34932577, Free PMC Article

    See all (114) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study identified that Shal/Kv4, a well known voltage-gated K+ channel, acts as a controller of wake-sleep transition at dusk in Drosophila circadian neurons.
      Title: Control of Sleep Onset by Shal/K(v)4 Channels in Drosophila Circadian Neurons.
    2. We found that ddaE neurons have an axonal diffusion barrier proximal to the cell body that requires a giant isoform of the neuronal ankyrin Ank2. Furthermore, the potassium channel shal concentrates in the proximal axon in an Ank2-dependent manner
      Title: Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment.
    3. The loss of Shal potassium channel induces compensatory rebalancing of ion channel expression.
      Title: Krüppel mediates the selective rebalancing of ion channel expression.
    4. In Drosophila, the single Shal/K(v)4 gene encodes the predominant I(A) current in many neuronal cell bodies.
      Title: Shal/K(v)4 channels are required for maintaining excitability during repetitive firing and normal locomotion in Drosophila.
    5. Data show that SIDL is expressed primarily in the nervous system, co-localizes with GFP-Shal channels in neurons, and interacts specifically with the LL-motif of Drosophila and mouse Shal channels.
      Title: SIDL interacts with the dendritic targeting motif of Shal (K(v)4) K+ channels in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables A-type (transient outward) potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables A-type (transient outward) potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in associative learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated potassium channel complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    shaker cognate l
    Names
    CG9262-PA
    CG9262-PB
    CG9262-PC
    Shaker-like
    Shal-PA
    Shal-PB
    Shal-PC
    shaker cognate 1
    shaker cognate L

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19566851..19584568 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104176.2 → NP_001097646.1  shaker cognate l, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097646.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JNV8, P17971, Q29R37, Q9VW11
      Conserved Domains (3) summary
      cd18420
      Location:6 → 144
      BTB_POZ_Shal-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins
      pfam00520
      Location:188 → 415
      Ion_trans; Ion transport protein
      pfam11879
      Location:445 → 540
      DUF3399; Domain of unknown function (DUF3399)

    2. NM_001275126.1 → NP_001262055.1  shaker cognate l, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262055.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFP1
      Conserved Domains (3) summary
      cd18420
      Location:6 → 144
      BTB_POZ_Shal-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins
      pfam00520
      Location:188 → 415
      Ion_trans; Ion transport protein
      pfam11879
      Location:445 → 490
      DUF3399; Domain of unknown function (DUF3399)

    3. NM_079435.4 → NP_524159.1  shaker cognate l, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524159.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P17971
      Related
      FBpp0074741
      Conserved Domains (3) summary
      cd18420
      Location:6 → 144
      BTB_POZ_Shal-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins
      pfam00520
      Location:188 → 415
      Ion_trans; Ion transport protein
      pfam11879
      Location:445 → 489
      DUF3399; Domain of unknown function (DUF3399)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFP1 M9PFP1
    P17971.2 P17971

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