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    RGS22 regulator of G protein signaling 22 [ Homo sapiens (human) ]

    Gene ID: 26166, updated on 3-Apr-2024

    Summary

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    Official Symbol
    RGS22provided by HGNC
    Official Full Name
    regulator of G protein signaling 22provided by HGNC
    Primary source
    HGNC:HGNC:24499
    See related
    Ensembl:ENSG00000132554 MIM:615650; AllianceGenome:HGNC:24499
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT145; PRTD-NY2
    Summary
    Enables G-protein alpha-subunit binding activity. Predicted to be involved in negative regulation of signal transduction. Located in actin cytoskeleton; cytosol; and fibrillar center. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 35.2), ovary (RPKM 3.9) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    8q22.2
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (99960936..100106049, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (101085830..101230841, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (100973164..101118277, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 13 homolog B Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:100782591-100783790 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:100871617-100872116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:100880771-100881278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:100883624-100884124 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:100904777-100905425 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:100905426-100906073 Neighboring gene MPRA-validated peak7123 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr8:100947244-100947479 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:100955411-100956610 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:100959374-100959874 Neighboring gene cytochrome c oxidase subunit 6C Neighboring gene small nucleolar RNA, C/D box 77B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27684 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19407 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19408 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:101162699-101163202 Neighboring gene F-box protein 43 Neighboring gene RNA polymerase II, I and III subunit K

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RGS22, a novel cancer/testis antigen, inhibits epithelial cell invasion and metastasis. Hu Y, et al. Clin Exp Metastasis, 2011 Aug. PMID 21533872
    2. miR-1260b promotes cell migration and invasion of hepatocellular carcinoma by targeting the regulator of G-protein signaling 22. Li X, et al. Biotechnol Lett, 2018 Jan. PMID 29038925
    3. RGS22 inhibits pancreatic adenocarcinoma cell migration through the G12/13 α subunit/F-actin pathway. Hu Y, et al. Oncol Rep, 2015 Nov. PMID 26323264
    4. RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits. Hu Y, et al. Biol Reprod, 2008 Dec. PMID 18703424
    5. Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma. Stacey SN, et al. Hum Mol Genet, 2014 Jun 1. PMID 24403052, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulator of G-protein signaling 22 (RGS22) was identified as a direct target of miR-1260b and was inhibited by miR-1260b. Knockdown of RGS22 increased proliferation of hepatocellular carcinoma cells.
      Title: miR-1260b promotes cell migration and invasion of hepatocellular carcinoma by targeting the regulator of G-protein signaling 22.
    2. RGS22 acts as a tumor suppressor, repressing human pancreatic adenocarcinoma cell migration by coupling to GNA12/13.
      Title: RGS22 inhibits pancreatic adenocarcinoma cell migration through the G12/13 α subunit/F-actin pathway.
    3. New basal cell carcinoma susceptibility loci were identified at TGM3 (rs214782) and RGS22(rs7006527).
      Title: Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.
    4. Over-expression of RGS22 in a highly metastatic esophageal cancer cell line causes decrease in cell migration and reduction in the invasive potential of the cells.
      Title: RGS22, a novel cancer/testis antigen, inhibits epithelial cell invasion and metastasis.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    7. RGS22 may also play a role in GNA13 translocation from the cytoplasm to the nucleus during spermiogenesis
      Title: RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ40080, FLJ75004, MGC102908, DKFZp434I092

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein alpha-subunit binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulator of G-protein signaling 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286692.2 → NP_001273621.1  regulator of G-protein signaling 22 isoform 2

      See identical proteins and their annotated locations for NP_001273621.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK292559, AP005356, BC092411, BM684810
      Consensus CDS
      CCDS69521.1
      UniProtKB/Swiss-Prot
      Q8NE09
      Related
      ENSP00000428212.1, ENST00000523437.5
      Conserved Domains (3) summary
      cd08725
      Location:1014 → 1136
      RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
      cd08726
      Location:841 → 970
      RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
      cd08727
      Location:658 → 773
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2

    2. NM_001286693.2 → NP_001273622.1  regulator of G-protein signaling 22 isoform 3

      See identical proteins and their annotated locations for NP_001273622.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC021590, AP005356, BC050053, BM684810
      Consensus CDS
      CCDS75775.1
      UniProtKB/TrEMBL
      G3V112
      Related
      ENSP00000429382.1, ENST00000523287.5
      Conserved Domains (3) summary
      cd08725
      Location:845 → 967
      RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
      cd08726
      Location:672 → 801
      RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
      cd08727
      Location:489 → 604
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2

    3. NM_015668.5 → NP_056483.3  regulator of G-protein signaling 22 isoform 1

      See identical proteins and their annotated locations for NP_056483.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC021590, AP005356, BC036665, BM684810
      Consensus CDS
      CCDS43758.1
      UniProtKB/Swiss-Prot
      A8K944, Q569L2, Q86Y71, Q8NE09, Q9BYZ4, Q9UFN6
      Related
      ENSP00000354109.6, ENST00000360863.11
      Conserved Domains (3) summary
      cd08725
      Location:1026 → 1148
      RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
      cd08726
      Location:853 → 982
      RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
      cd08727
      Location:670 → 785
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      99960936..100106049 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013310.3 → XP_016868799.1  regulator of G-protein signaling 22 isoform X7

    2. XM_017013309.3 → XP_016868798.1  regulator of G-protein signaling 22 isoform X5

    3. XM_005250856.4 → XP_005250913.1  regulator of G-protein signaling 22 isoform X2

      Conserved Domains (3) summary
      cd08725
      Location:973 → 1095
      RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
      cd08727
      Location:670 → 785
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
      cl02565
      Location:853 → 931
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    4. XM_047421681.1 → XP_047277637.1  regulator of G-protein signaling 22 isoform X6

    5. XM_005250858.4 → XP_005250915.1  regulator of G-protein signaling 22 isoform X3

      Conserved Domains (3) summary
      cd08726
      Location:853 → 982
      RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
      cd08727
      Location:670 → 785
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
      cl02565
      Location:1005 → 1094
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    6. XM_005250857.4 → XP_005250914.1  regulator of G-protein signaling 22 isoform X1

      Conserved Domains (3) summary
      cd08726
      Location:853 → 982
      RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
      cd08727
      Location:670 → 785
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
      cl02565
      Location:1026 → 1120
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    7. XM_047421679.1 → XP_047277635.1  regulator of G-protein signaling 22 isoform X4

    8. XM_017013311.2 → XP_016868800.1  regulator of G-protein signaling 22 isoform X9

      UniProtKB/TrEMBL
      B3KUK3

    9. XM_024447121.2 → XP_024302889.1  regulator of G-protein signaling 22 isoform X11

      UniProtKB/TrEMBL
      B3KUK3
      Related
      ENST00000517769.5
      Conserved Domains (3) summary
      cd08725
      Location:415 → 537
      RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
      cd08726
      Location:242 → 371
      RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
      cd08727
      Location:59 → 174
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2

    10. XM_005250860.4 → XP_005250917.1  regulator of G-protein signaling 22 isoform X8

      UniProtKB/TrEMBL
      B4DYK1
      Conserved Domains (1) summary
      cd08727
      Location:670 → 785
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2

    11. XM_047421682.1 → XP_047277638.1  regulator of G-protein signaling 22 isoform X12

    12. XM_011516959.4 → XP_011515261.1  regulator of G-protein signaling 22 isoform X10

      Conserved Domains (1) summary
      cl02565
      Location:670 → 722
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      101085830..101230841 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360268.1 → XP_054216243.1  regulator of G-protein signaling 22 isoform X7

    2. XM_054360266.1 → XP_054216241.1  regulator of G-protein signaling 22 isoform X5

    3. XM_054360263.1 → XP_054216238.1  regulator of G-protein signaling 22 isoform X2

    4. XM_054360267.1 → XP_054216242.1  regulator of G-protein signaling 22 isoform X6

    5. XM_054360264.1 → XP_054216239.1  regulator of G-protein signaling 22 isoform X3

    6. XM_054360262.1 → XP_054216237.1  regulator of G-protein signaling 22 isoform X1

    7. XM_054360265.1 → XP_054216240.1  regulator of G-protein signaling 22 isoform X4

    8. XM_054360270.1 → XP_054216245.1  regulator of G-protein signaling 22 isoform X9

    9. XM_054360272.1 → XP_054216247.1  regulator of G-protein signaling 22 isoform X11

    10. XM_054360269.1 → XP_054216244.1  regulator of G-protein signaling 22 isoform X8

    11. XM_054360273.1 → XP_054216248.1  regulator of G-protein signaling 22 isoform X12

    12. XM_054360271.1 → XP_054216246.1  regulator of G-protein signaling 22 isoform X10

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NE09.3 GenPept UniProtKB/Swiss-Prot:Q8NE09

    Gene LinkOut

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