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    SLC5A9 solute carrier family 5 member 9 [ Homo sapiens (human) ]

    Gene ID: 200010, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SLC5A9provided by HGNC
    Official Full Name
    solute carrier family 5 member 9provided by HGNC
    Primary source
    HGNC:HGNC:22146
    See related
    Ensembl:ENSG00000117834 MIM:620216; AllianceGenome:HGNC:22146
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SGLT4
    Summary
    Predicted to enable glucose:sodium symporter activity. Predicted to be involved in sodium ion transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in duodenum (RPKM 15.3), small intestine (RPKM 14.5) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1p33
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (48222716..48248638)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (48090656..48127385)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (48688388..48714310)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2794 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:48558178-48559377 Neighboring gene cytochrome P450 family 46 subfamily A member 4, pseudogene Neighboring gene Skint1 like (pseudogene) Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:48674527-48675206 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:48679855-48680592 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:48697245-48697746 Neighboring gene spermatogenesis associated 6 Neighboring gene protein phosphatase 1 regulatory subunit 8 pseudogene 1 Neighboring gene RNA, U6 small nuclear 723, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose. Tazawa S, et al. Life Sci, 2005 Jan 14. PMID 15607332
    2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. Flachsbart F, et al. Mutat Res, 2010 Dec 10. PMID 20800603
    3. Human transcription factor protein interaction networks. Göös H, et al. Nat Commun, 2022 Feb 9. PMID 35140242, Free PMC Article
    4. Physical and functional interactome atlas of human receptor tyrosine kinases. Salokas K, et al. EMBO Rep, 2022 Jun 7. PMID 35384245, Free PMC Article
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
    2. SGLT4 would have unique physiological functions (i.e., absorption and/or reabsorption of Man, 1,5AG, and Fru, in addition to Glc).
      Title: SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC132517, MGC132523

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glucose:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables low-affinity glucose:sodium symporter activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hexose transmembrane transport TAS
    Traceable Author Statement
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    sodium/glucose cotransporter 4
    Names
    Na(+)/glucose cotransporter 4
    hSGLT4
    solute carrier family 5 (sodium/glucose cotransporter), member 9
    solute carrier family 5 (sodium/sugar cotransporter), member 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011547.3 → NP_001011547.2  sodium/glucose cotransporter 4 isoform 2

      See identical proteins and their annotated locations for NP_001011547.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the mid coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AI767388, AL109659, BC104857
      Consensus CDS
      CCDS30709.2
      UniProtKB/Swiss-Prot
      B3KY87, B7ZL45, B7ZL47, E9PAK4, E9PJ08, Q2M3M2, Q5TET3
      Related
      ENSP00000401730.2, ENST00000438567.7
      Conserved Domains (1) summary
      cd11488
      Location:37 → 681
      SLC5sbd_SGLT4; Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain

    2. NM_001135181.2 → NP_001128653.1  sodium/glucose cotransporter 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI767388, AL109659, BC104857, BX648549
      Consensus CDS
      CCDS44136.1
      UniProtKB/Swiss-Prot
      Q2M3M2
      Related
      ENSP00000236495.5, ENST00000236495.9
      Conserved Domains (1) summary
      cd11488
      Location:37 → 706
      SLC5sbd_SGLT4; Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      48222716..48248638
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448583.1 → XP_047304539.1  sodium/glucose cotransporter 4 isoform X1

      Related
      ENST00000493837.6

    2. XM_011540924.3 → XP_011539226.1  sodium/glucose cotransporter 4 isoform X2

      Conserved Domains (1) summary
      cl00456
      Location:37 → 719
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. XM_047448585.1 → XP_047304541.1  sodium/glucose cotransporter 4 isoform X3

    4. XM_047448592.1 → XP_047304548.1  sodium/glucose cotransporter 4 isoform X5

    5. XM_011540925.3 → XP_011539227.1  sodium/glucose cotransporter 4 isoform X4

      Conserved Domains (1) summary
      cl00456
      Location:37 → 641
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    6. XM_047448596.1 → XP_047304552.1  sodium/glucose cotransporter 4 isoform X7

    7. XM_011540929.3 → XP_011539231.1  sodium/glucose cotransporter 4 isoform X9

      Conserved Domains (1) summary
      cl00456
      Location:37 → 444
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    8. XM_047448593.1 → XP_047304549.1  sodium/glucose cotransporter 4 isoform X6

    9. XM_011540927.2 → XP_011539229.1  sodium/glucose cotransporter 4 isoform X8

      Conserved Domains (1) summary
      cl00456
      Location:91 → 586
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      48090656..48127385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334923.1 → XP_054190898.1  sodium/glucose cotransporter 4 isoform X11

    2. XM_054334924.1 → XP_054190899.1  sodium/glucose cotransporter 4 isoform X5

    3. XM_054334918.1 → XP_054190893.1  sodium/glucose cotransporter 4 isoform X1

    4. XM_054334919.1 → XP_054190894.1  sodium/glucose cotransporter 4 isoform X2

    5. XM_054334920.1 → XP_054190895.1  sodium/glucose cotransporter 4 isoform X10

    6. XM_054334921.1 → XP_054190896.1  sodium/glucose cotransporter 4 isoform X3

    7. XM_054334922.1 → XP_054190897.1  sodium/glucose cotransporter 4 isoform X4

    8. XM_054334926.1 → XP_054190901.1  sodium/glucose cotransporter 4 isoform X7

    9. XM_054334928.1 → XP_054190903.1  sodium/glucose cotransporter 4 isoform X9

    10. XM_054334925.1 → XP_054190900.1  sodium/glucose cotransporter 4 isoform X6

    11. XM_054334927.1 → XP_054190902.1  sodium/glucose cotransporter 4 isoform X8

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2M3M2.2 GenPept UniProtKB/Swiss-Prot:Q2M3M2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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