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    APH1A aph-1 homolog A, gamma-secretase subunit [ Sus scrofa (pig) ]

    Gene ID: 100154978, updated on 8-Mar-2024

    Summary

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    Official Symbol
    APH1Aprovided by VGNC
    Official Full Name
    aph-1 homolog A, gamma-secretase subunitprovided by VGNC
    Primary source
    VGNC:VGNC:85409
    See related
    Ensembl:ENSSSCG00000028297
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Ubiquitous expression in lung (RPKM 53.9), kidney (RPKM 48.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 4 NC_010446.5 (98817574..98821255)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) Unplaced Scaffold NW_003538109.2 (12830..16760, complement)

    Chromosome 4 - NC_010446.5Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S21 Neighboring gene circadian associated repressor of transcription Neighboring gene chromosome 4 C1orf54 homolog Neighboring gene carbonic anhydrase 14 Neighboring gene acidic nuclear phosphoprotein 32 family member E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Comparative analysis of protein coding sequences from human, mouse and the domesticated pig. Jørgensen FG, et al. BMC Biol, 2005 Jan 28. PMID 15679890, Free PMC Article
    2. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch receptor processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of gamma-secretase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gamma-secretase subunit APH-1A
    Names
    anterior pharynx defective 1 homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244487.1 → NP_001231416.1  gamma-secretase subunit APH-1A

      Status: PROVISIONAL

      Source sequence(s)
      AY609845, BW976365, DN121186
      UniProtKB/TrEMBL
      A0A480ZS76, A0A4X1SIA7, I3L8R2
      Related
      ENSSSCP00000020423.2, ENSSSCT00000023376.4
      Conserved Domains (1) summary
      pfam06105
      Location:3 → 233
      Aph-1; Aph-1 protein

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010446.5 Reference Sscrofa11.1 Primary Assembly

      Range
      98817574..98821255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021088563.1 → XP_020944222.1  gamma-secretase subunit APH-1A isoform X1

      UniProtKB/TrEMBL
      A0A287B0C6, A0A4X1SH86, A0A4X1SH94, A0A8D0IT63
      Conserved Domains (1) summary
      pfam06105
      Location:3 → 233
      Aph-1; Aph-1 protein
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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