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SUV2 protein dimerization [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834601, updated on 6-Oct-2023

Summary

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Gene symbol
SUV2
Gene description
protein dimerization
Primary source
Araport:AT5G45610
Locus tag
AT5G45610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
MRA19.1; MRA19_1; SENSITIVE TO UV 2
Summary
Encodes a homologue of the ATR-interacting protein ATRIP. Mutant (named sensitive to UV2 or suv2) is UVB-hypersensitive and defective in DNA damage response.
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Genomic context

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Location:
chromosome: 5
Exon count:
12
Sequence:
Chromosome: 5; NC_003076.8 (18496228..18499888, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Proteasome component (PCI) domain protein Neighboring gene senescence regulator (Protein of unknown function, DUF584)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SUV2, which encodes an ATR-related cell cycle checkpoint and putative plant ATRIP, is required for aluminium-dependent root growth inhibition in Arabidopsis. Sjogren CA, et al. Plant Cell Environ, 2017 Sep. PMID 28556304
  2. A UVB-hypersensitive mutant in Arabidopsis thaliana is defective in the DNA damage response. Sakamoto AN, et al. Plant J, 2009 Nov. PMID 19619159
  3. The Arabidopsis ATRIP ortholog is required for a programmed response to replication inhibitors. Sweeney PR, et al. Plant J, 2009 Nov. PMID 19619158
  4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SUV2 was determined to be required for halting cell cycle progression and triggering loss of the quiescent centre (QC) following exposure to Aluminum.
    Title: SUV2, which encodes an ATR-related cell cycle checkpoint and putative plant ATRIP, is required for aluminium-dependent root growth inhibition in Arabidopsis.
  2. Data suggest that in Arabidopsis, as in yeast and animals, ATRIP acts in complex with ATR (ataxia telangiectasia mutated and rad3-related) to regulate cellular responses to replication blocks and DNA damage. [ATRIP]
    Title: The Arabidopsis ATRIP ortholog is required for a programmed response to replication inhibitors.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_001344635.1
NM_123929.6

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein dimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell cycle G2/M phase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to UV-B IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to aluminum ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to aluminum ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to cisplatin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to hydroxyurea IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
protein dimerization
NP_199374.4
  • SENSITIVE TO UV 2 (SUV2); Has 65 Blast hits to 63 proteins in 29 species: Archae - 0; Bacteria - 2; Metazoa - 9; Fungi - 13; Plants - 35; Viruses - 0; Other Eukaryotes - 6 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    18496228..18499888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_123929.6 → NP_199374.4  protein dimerization [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_199374.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A1P8BEL4, C8KI33, Q9FK80
    UniProtKB/TrEMBL
    A0A178U969, A0A5S9YBU4
    Conserved Domains (1) summary
    PLN03205
    Location:1 → 646
    PLN03205; ATR interacting protein; Provisional

  2. NM_001344635.1 → NP_001331674.1  protein dimerization [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654G865
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C8KI33.1

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