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    MCA1 PLAC8 family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829747, updated on 7-Sep-2023

    Summary

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    Gene symbol
    MCA1
    Gene description
    PLAC8 family protein
    Primary source
    Araport:AT4G35920
    Locus tag
    AT4G35920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    mid1-complementing activity 1; T19K4.50
    Summary
    Encodes an integral plasma membrane protein. Functionally complements the yeast mid1 mutant, a deficiency of Ca2+ influx. Involved in Ca2+ influx and mechanical sensing in roots. An over-expression line showed increased Ca2+ uptake than the wild type plant. The primary root of a knock-out mutant failed to penetrate a harder agar medium from a softer medium.
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (17011788..17015493, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Trm112p-like protein Neighboring gene Adenine nucleotide alpha hydrolases-like superfamily protein Neighboring gene F-box family protein Neighboring gene uncharacterized protein Neighboring gene RAC-like 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The gravistimulation-induced very slow Ca(2+) increase in Arabidopsis seedlings requires MCA1, a Ca(2+)-permeable mechanosensitive channel. Nakano M, et al. Sci Rep, 2021 Jan 8. PMID 33420331, Free PMC Article
    2. Expression of Arabidopsis MCA1 enhanced mechanosensitive channel activity in the Xenopus laevis oocyte plasma membrane. Furuichi T, et al. Plant Signal Behav, 2012 Aug. PMID 22751361, Free PMC Article
    3. Arabidopsis plasma membrane protein crucial for Ca2+ influx and touch sensing in roots. Nakagawa Y, et al. Proc Natl Acad Sci U S A, 2007 Feb 27. PMID 17360695, Free PMC Article
    4. The root growth reduction in response to mechanical stress involves ethylene-mediated microtubule reorganization and transmembrane receptor-mediated signal transduction in Arabidopsis. Okamoto T, et al. Plant Cell Rep, 2021 Mar. PMID 33439322
    5. Ca(2+)-permeable mechanosensitive channels MCA1 and MCA2 mediate cold-induced cytosolic Ca(2+) increase and cold tolerance in Arabidopsis. Mori K, et al. Sci Rep, 2018 Jan 11. PMID 29323146, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The gravistimulation-induced very slow Ca(2+) increase in Arabidopsis seedlings requires MCA1, a Ca(2+)-permeable mechanosensitive channel.
      Title: The gravistimulation-induced very slow Ca(2+) increase in Arabidopsis seedlings requires MCA1, a Ca(2+)-permeable mechanosensitive channel.
    2. The root growth reduction in response to mechanical stress involves ethylene-mediated microtubule reorganization and transmembrane receptor-mediated signal transduction in Arabidopsis.
      Title: The root growth reduction in response to mechanical stress involves ethylene-mediated microtubule reorganization and transmembrane receptor-mediated signal transduction in Arabidopsis.
    3. VIP1 and its close homologues can interact with calmodulins. Their nuclear-cytoplasmic shuttling requires neither MCA1 nor MCA2, but does require calcium signalling. Salt stress affects the VIP1-dependent regulation of root bending.
      Title: Calcium signalling regulates the functions of the bZIP protein VIP1 in touch responses in Arabidopsis thaliana.
    4. MCA1 is involved in the cold-induced elevation of [Ca2+]cyt, cold tolerance, and CBF/DREB1-independent cold signaling.
      Title: Ca(2+)-permeable mechanosensitive channels MCA1 and MCA2 mediate cold-induced cytosolic Ca(2+) increase and cold tolerance in Arabidopsis.
    5. Transmembrane Topologies of Ca2+-permeable Mechanosensitive Channels MCA1 and MCA2 in Arabidopsis thaliana.
      Title: Transmembrane Topologies of Ca2+-permeable Mechanosensitive Channels MCA1 and MCA2 in Arabidopsis thaliana.
    6. MCA1 encodes a possible mechanosensitive channel with a conductance of 34 pS.
      Title: Expression of Arabidopsis MCA1 enhanced mechanosensitive channel activity in the Xenopus laevis oocyte plasma membrane.
    7. The N-terminal half of both proteins with the EF hand-like region is necessary and sufficient for Ca(2+) uptake and that the coiled-coil motif regulates MCA1 negatively and MCA2 positively.
      Title: Determination of structural regions important for Ca(2+) uptake activity in Arabidopsis MCA1 and MCA2 expressed in yeast.
    8. mca1-null mca2-null double mutants are defective in Ca2+ uptake from the roots and have a slow growth phenotype.
      Title: MCA1 and MCA2 that mediate Ca2+ uptake have distinct and overlapping roles in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001342380.1
    NM_001342381.1
    NM_119759.4
    NM_179172.3
    NM_179173.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within carbohydrate homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within osmosensory signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    PLAC8 family protein
    NP_195317.2
    • mid1-complementing activity 1 (MCA1); CONTAINS InterPro DOMAIN/s: Protein of unknown function Cys-rich (InterPro:IPR006461); BEST Arabidopsis thaliana protein match is: PLAC8 family protein (TAIR:AT2G17780.1); Has 655 Blast hits to 652 proteins in 78 species: Archae - 0; Bacteria - 2; Metazoa - 56; Fungi - 47; Plants - 535; Viruses - 0; Other Eukaryotes - 15 (source: NCBI BLink).
    NP_849503.1
    • mid1-complementing activity 1 (MCA1); CONTAINS InterPro DOMAIN/s: Protein of unknown function Cys-rich (InterPro:IPR006461); BEST Arabidopsis thaliana protein match is: PLAC8 family protein (TAIR:AT2G17780.1); Has 655 Blast hits to 652 proteins in 78 species: Archae - 0; Bacteria - 2; Metazoa - 56; Fungi - 47; Plants - 535; Viruses - 0; Other Eukaryotes - 15 (source: NCBI BLink).
    NP_849504.2
    • mid1-complementing activity 1 (MCA1); CONTAINS InterPro DOMAIN/s: Protein of unknown function Cys-rich (InterPro:IPR006461); BEST Arabidopsis thaliana protein match is: PLAC8 family protein (TAIR:AT2G17780.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      17011788..17015493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119759.4 → NP_195317.2  PLAC8 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195317.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65629, Q8L7E9, Q9ASR5
      UniProtKB/TrEMBL
      A0A178UWW3, A0A5S9XZ16, B9DHB2
      Conserved Domains (2) summary
      TIGR01571
      Location:298 → 400
      A_thal_Cys_rich; uncharacterized Cys-rich domain
      cd21037
      Location:22 → 149
      MLKL_NTD; N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins

    2. NM_179172.3 → NP_849503.1  PLAC8 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849503.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65629, Q8L7E9, Q9ASR5
      UniProtKB/TrEMBL
      A0A178UWW3, A0A5S9XZ16, B9DHB2
      Conserved Domains (2) summary
      TIGR01571
      Location:298 → 400
      A_thal_Cys_rich; uncharacterized Cys-rich domain
      cd21037
      Location:22 → 149
      MLKL_NTD; N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins

    3. NM_001342380.1 → NP_001329715.1  PLAC8 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65629, Q8L7E9, Q9ASR5
      UniProtKB/TrEMBL
      A0A178UWW3, A0A5S9XZ16, B9DHB2
      Conserved Domains (2) summary
      TIGR01571
      Location:298 → 400
      A_thal_Cys_rich; uncharacterized Cys-rich domain
      cd21037
      Location:22 → 149
      MLKL_NTD; N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins

    4. NM_179173.4 → NP_849504.2  PLAC8 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849504.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65629, Q8L7E9, Q9ASR5
      UniProtKB/TrEMBL
      A0A178UWW3, A0A5S9XZ16, B9DHB2
      Conserved Domains (2) summary
      TIGR01571
      Location:298 → 400
      A_thal_Cys_rich; uncharacterized Cys-rich domain
      cd21037
      Location:22 → 149
      MLKL_NTD; N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins

    5. NM_001342381.1 → NP_001329716.1  PLAC8 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65629, Q8L7E9, Q9ASR5
      UniProtKB/TrEMBL
      A0A178UWW3, A0A5S9XZ16, B9DHB2
      Conserved Domains (2) summary
      TIGR01571
      Location:298 → 400
      A_thal_Cys_rich; uncharacterized Cys-rich domain
      cd21037
      Location:22 → 149
      MLKL_NTD; N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L7E9.1

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