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    sago-2 Piwi domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171653, updated on 11-Apr-2024

    Summary

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    Gene symbol
    sago-2
    Gene description
    Piwi domain-containing protein
    Primary source
    WormBase:WBGene00018921
    Locus tag
    CELE_F56A6.1
    See related
    AllianceGenome:WB:WBGene00018921
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable nucleic acid binding activity. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (618160..621490)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Unconventional myosin-IXa-like Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Crossover junction endonuclease MUS81;ERCC4 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Eukaryotic initiation factor 4A-III;RNA helicase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Vasa Homolog RDE-12 engages target mRNA and multiple argonaute proteins to promote RNAi in C. elegans. Shirayama M, et al. Curr Biol, 2014 Apr 14. PMID 24684931, Free PMC Article
    2. Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint. Gu SG, et al. Nat Genet, 2012 Jan 8. PMID 22231482, Free PMC Article
    3. ELLI-1, a novel germline protein, modulates RNAi activity and P-granule accumulation in Caenorhabditis elegans. Andralojc KM, et al. PLoS Genet, 2017 Feb. PMID 28182654, Free PMC Article
    4. Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. Yigit E, et al. Cell, 2006 Nov 17. PMID 17110334
    5. Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline. Das PP, et al. Mol Cell, 2008 Jul 11. PMID 18571451, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RISC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Piwi domain-containing protein
    NP_001379987.1
    • Confirmed by transcript evidence
    NP_490758.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      618160..621490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058357.4 → NP_490758.1  Piwi domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490758.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0U1RML5
      Conserved Domains (2) summary
      cd02826
      Location:444 → 849
      Piwi-like; Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The ...
      cd02846
      Location:272 → 389
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...

    2. NM_001392310.1 → NP_001379987.1  Piwi domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0U1RML6
      Conserved Domains (2) summary
      cd02826
      Location:444 → 849
      Piwi-like; PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The central component ...
      cd02846
      Location:272 → 389
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    Nucleotide Protein
    Heading Accession and Version

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