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    LUP1 lupeol synthase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844237, updated on 15-Oct-2023

    Summary

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    Gene symbol
    LUP1
    Gene description
    lupeol synthase 1
    Primary source
    Araport:AT1G78970
    Locus tag
    AT1G78970
    See related
    TAIR:AT1G78970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA LUPEOL SYNTHASE 1; ATLUP1; lupeol synthase 1
    Summary
    Lupeol synthase. Converts oxidosqualene to multiple triterpene alcohols and a triterpene diols. This conversion proceeds through the formation of a 17beta-dammarenyl cation.
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    Genomic context

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    See LUP1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    18
    Sequence:
    Chromosome: 1; NC_003070.9 (29703055..29708175)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene camelliol C synthase 1 Neighboring gene lupeol synthase 2 Neighboring gene STRUBBELIG-receptor family 5 Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and reactivity of the dammarenyl cation: configurational transmission in triterpene synthesis. Xiong Q, et al. J Org Chem, 2005 Jul 8. PMID 15989315
    2. Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene. Herrera JB, et al. Phytochemistry, 1998 Dec. PMID 9883589
    3. A DEK domain-containing protein modulates chromatin structure and function in Arabidopsis. Waidmann S, et al. Plant Cell, 2014 Nov. PMID 25387881, Free PMC Article
    4. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001334865.1
    NM_106546.3
    NM_179572.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables beta-amyrin synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lupan-3beta,20-diol synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lupeol synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lupeol synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within pentacyclic triterpenoid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in triterpenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    lupeol synthase 1
    NP_178018.1
    • lupeol synthase 1 (LUP1); CONTAINS InterPro DOMAIN/s: Terpene synthase, conserved site (InterPro:IPR002365), Terpenoid cylases/protein prenyltransferase alpha-alpha toroid (InterPro:IPR008930), Squalene cyclase (InterPro:IPR018333), Prenyltransferase/squalene oxidase (InterPro:IPR001330); BEST Arabidopsis thaliana protein match is: lupeol synthase 2 (TAIR:AT1G78960.1); Has 2106 Blast hits to 1984 proteins in 578 species: Archae - 2; Bacteria - 957; Metazoa - 82; Fungi - 241; Plants - 614; Viruses - 0; Other Eukaryotes - 210 (source: NCBI BLink).
    NP_849903.1
    • lupeol synthase 1 (LUP1); CONTAINS InterPro DOMAIN/s: Terpene synthase, conserved site (InterPro:IPR002365), Terpenoid cylases/protein prenyltransferase alpha-alpha toroid (InterPro:IPR008930), Squalene cyclase (InterPro:IPR018333), Prenyltransferase/squalene oxidase (InterPro:IPR001330); BEST Arabidopsis thaliana protein match is: lupeol synthase 2 (TAIR:AT1G78960.1); Has 2106 Blast hits to 1984 proteins in 578 species: Archae - 2; Bacteria - 957; Metazoa - 82; Fungi - 241; Plants - 614; Viruses - 0; Other Eukaryotes - 210 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      29703055..29708175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106546.3 → NP_178018.1  lupeol synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178018.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49985, O64551, P92977, Q9C5M3
      UniProtKB/TrEMBL
      A0A178WLB6, A0A5S9WVL5, A0A654EQ84
      Conserved Domains (1) summary
      PLN02993
      Location:1 → 757
      PLN02993; lupeol synthase

    2. NM_001334865.1 → NP_001321029.1  lupeol synthase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49985, O64551, P92977, Q9C5M3
      UniProtKB/TrEMBL
      A0A178WLB6, A0A5S9WVL5, A0A654EQ84
      Conserved Domains (1) summary
      PLN02993
      Location:1 → 757
      PLN02993; lupeol synthase

    3. NM_179572.2 → NP_849903.1  lupeol synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849903.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49985, O64551, P92977, Q9C5M3
      UniProtKB/TrEMBL
      A0A178WLB6, A0A5S9WVL5, A0A654EQ84
      Conserved Domains (1) summary
      PLN02993
      Location:1 → 757
      PLN02993; lupeol synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5M3.1

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