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    SIK1 Protein kinase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843253, updated on 6-Oct-2023

    Summary

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    Gene symbol
    SIK1
    Gene description
    Protein kinase superfamily protein
    Primary source
    Araport:AT1G69220
    Locus tag
    AT1G69220
    See related
    TAIR:AT1G69220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F4N2.24; SERINE/THREONINE KINASE SIK1
    Summary
    Encodes a putative serine/threonine kinase (SIK1).
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    Genomic context

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    See SIK1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    18
    Sequence:
    Chromosome: 1; NC_003070.9 (26020089..26026285, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene fructokinase-like protein Neighboring gene Uncharacterized protein family UPF0090 Neighboring gene SPIRAL1-like2 Neighboring gene methyl esterase 15 Neighboring gene Nuclear transport factor 2 (NTF2) family protein with RNA binding (RRM-RBD-RNP motifs) domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The MAP4 Kinase SIK1 Ensures Robust Extracellular ROS Burst and Antibacterial Immunity in Plants. Zhang M, et al. Cell Host Microbe, 2018 Sep 12. PMID 30212650, Free PMC Article
    2. The Arabidopsis STE20/Hippo kinase SIK1 regulates polarity independently of PIN proteins. Zhang P, et al. Biochem Biophys Res Commun, 2021 Apr 16. PMID 33652206
    3. The Hippo/STE20 homolog SIK1 interacts with MOB1 to regulate cell proliferation and cell expansion in Arabidopsis. Xiong J, et al. J Exp Bot, 2016 Mar. PMID 26685188
    4. Molecular dissection of plant cytokinesis and phragmoplast structure: a survey of GFP-tagged proteins. Van Damme D, et al. Plant J, 2004 Nov. PMID 15469496
    5. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Arabidopsis STE20/Hippo kinase SIK1 regulates polarity independently of PIN proteins.
      Title: The Arabidopsis STE20/Hippo kinase SIK1 regulates polarity independently of PIN proteins.
    2. SIK1 positively regulates immunity by stabilizing BIK1 and activating RBOHD to promote the extracellular reactive oxygen species burst.
      Title: The MAP4 Kinase SIK1 Ensures Robust Extracellular ROS Burst and Antibacterial Immunity in Plants.
    3. The interaction between SIK1 and MOB1 was found to be mediated by an N-terminal domain of SIK1 and was further confirmed by bimolecular fluorescence complementation.
      Title: The Hippo/STE20 homolog SIK1 interacts with MOB1 to regulate cell proliferation and cell expansion in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_105589.4
    NM_179534.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of reactive oxygen species biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to molecule of bacterial origin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome HDA PubMed 
    located_in chromosome, centromeric region HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein kinase superfamily protein
    NP_564955.1
    • SIK1; FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: mitochondrion, chromosome, centromeric region, chromosome, nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT1G53165.2); Has 137554 Blast hits to 133946 proteins in 4802 species: Archae - 182; Bacteria - 16401; Metazoa - 51341; Fungi - 13391; Plants - 33553; Viruses - 570; Other Eukaryotes - 22116 (source: NCBI BLink).
    NP_849865.1
    • SIK1; FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: mitochondrion, chromosome, centromeric region, chromosome, nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT1G53165.2); Has 135073 Blast hits to 131353 proteins in 4820 species: Archae - 174; Bacteria - 17099; Metazoa - 50056; Fungi - 12728; Plants - 33057; Viruses - 559; Other Eukaryotes - 21400 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      26020089..26026285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105589.4 → NP_564955.1  Protein kinase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564955.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O24527, Q56WD6, Q56WZ7, Q8VYC1, Q9LQA1
      UniProtKB/TrEMBL
      A0A654EP23, A0A7G2E3P7
      Conserved Domains (1) summary
      cd06613
      Location:248 → 503
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    2. NM_179534.2 → NP_849865.1  Protein kinase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849865.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2E3P7
      Conserved Domains (2) summary
      smart00220
      Location:230 → 476
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06613
      Location:230 → 476
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O24527.1

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