ATSBT5.2 Subtilisin-like serine endopeptidase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: ATSBT5.2
Gene description: Subtilisin-like serine endopeptidase family protein
Primary source: Araport:AT1G20160
Locus tag: AT1G20160
See related: TAIR:AT1G20160
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: T20H2.6; T20H2_6
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Genomic context

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See ATSBT5.2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 10

Sequence:: Chromosome: 1; NC_003070.9 (6990642..6993989, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The SBT5.2 gene produces two distinct transcripts encoding a canonical secreted subtilase [SBT5.2(a)] and an intracellular protein [SBT5.2(b)]. SBT5.2(b) localizes to endosomes where it interacts with and retains the defence-related transcription factor MYB30.[SBT5.2]
Title: A non canonical subtilase attenuates the transcriptional activation of defence responses in Arabidopsis thaliana.
CO2-induced extracellular protease, CRSP (CO2 RESPONSE SECRETED PROTEASE), is a mediator of CO2-controlled stomatal development. [CRSP] [CO2 RESPONSE SECRETED PROTEASE]
Title: Carbonic anhydrases, EPF2 and a novel protease mediate CO2 control of stomatal development.

Submit: New GeneRIF Correction

General gene information

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Markers

At-10C-518 (e-PCR)
- UniSTS:229372

Homology

Orthologs from OrthoDB

NM_001035993.1

Supported by ESTs:

NM_001332439.1

Supported by ESTs:

NM_101870.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	NAS Non-traceable Author Statement more info	PubMed
enables serine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables tripeptidyl-peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of stomatal complex development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of stomatal complex development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to carbon dioxide	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apoplast	HDA more info	PubMed
located_in apoplast	IDA Inferred from Direct Assay more info
colocalizes_with endosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Subtilisin-like serine endopeptidase family protein

NP_001031070.1

ATSBT5.2; FUNCTIONS IN: identical protein binding, serine-type endopeptidase activity; INVOLVED IN: proteolysis, negative regulation of catalytic activity; LOCATED IN: apoplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Protease-associated PA (InterPro:IPR003137), Peptidase S8/S53, subtilisin/kexin/sedolisin (InterPro:IPR000209), Peptidase S8, subtilisin-related (InterPro:IPR015500), Proteinase inhibitor I9, subtilisin propeptide (InterPro:IPR010259), Peptidase S8/S53, subtilisin, active site (InterPro:IPR022398); BEST Arabidopsis thaliana protein match is: Subtilisin-like serine endopeptidase family protein (TAIR:AT1G20150.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_564107.1

ATSBT5.2; FUNCTIONS IN: identical protein binding, serine-type endopeptidase activity; INVOLVED IN: proteolysis, negative regulation of catalytic activity; LOCATED IN: apoplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Protease-associated PA (InterPro:IPR003137), Proteinase inhibitor, propeptide (InterPro:IPR009020), Peptidase S8/S53, subtilisin/kexin/sedolisin (InterPro:IPR000209), Peptidase S8, subtilisin-related (InterPro:IPR015500), Proteinase inhibitor I9, subtilisin propeptide (InterPro:IPR010259), Peptidase S8/S53, subtilisin, active site (InterPro:IPR022398); BEST Arabidopsis thaliana protein match is: Subtilisin-like serine endopeptidase family protein (TAIR:AT1G20150.1); Has 8668 Blast hits to 7419 proteins in 1217 species: Archae - 260; Bacteria - 4948; Metazoa - 184; Fungi - 671; Plants - 1928; Viruses - 0; Other Eukaryotes - 677 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

6990642..6993989 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_101870.3 → NP_564107.1 Subtilisin-like serine endopeptidase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_564107.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4HSQ4, Q8LAE1, Q9LNU1

UniProtKB/TrEMBL

A0A5S9V9J4

Conserved Domains (5) summary

cd04852
Location:105 → 580

Peptidases_S8_3; Peptidase S8 family domain, uncharacterized subfamily 3

COG1404
Location:481 → 640

AprE; Serine protease, subtilisin family [Posttranslational modification, protein turnover, chaperones]

cd02120
Location:345 → 476

PA_subtilisin_like; Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from Alnus glutinosa ag12, ...

pfam05922
Location:35 → 108

Inhibitor_I9; Peptidase inhibitor I9

pfam17766
Location:666 → 761

fn3_6; Fibronectin type-III domain
NM_001332439.1 → NP_001322709.1 Subtilisin-like serine endopeptidase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AUU9
NM_001035993.1 → NP_001031070.1 Subtilisin-like serine endopeptidase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001031070.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A654ECA4

Conserved Domains (4) summary

cd04852
Location:66 → 541

Peptidases_S8_3; Peptidase S8 family domain, uncharacterized subfamily 3

cd02120
Location:306 → 437

PA_subtilisin_like; PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from ...

pfam00082
Location:101 → 548

Peptidase_S8; Subtilase family

pfam05922
Location:28 → 69

Inhibitor_I9; Peptidase inhibitor I9