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    RBOHD respiratory burst oxidase homologue D [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834842, updated on 14-Feb-2024

    Summary

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    Gene symbol
    RBOHD
    Gene description
    respiratory burst oxidase homologue D
    Primary source
    Araport:AT5G47910
    Locus tag
    AT5G47910
    See related
    TAIR:AT5G47910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRBOHD; MCA23.25; MCA23_25; RESPIRATORY BURST OXIDASE; respiratory burst oxidase homologue D
    Summary
    NADPH/respiratory burst oxidase protein D (RbohD).Interacts with AtrbohF gene to fine tune the spatial control of ROI production and hypersensitive response to cell in and around infection site.
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    Genomic context

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    See RBOHD in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (19397041..19402061)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene NADH-ubiquinone oxidoreductase B8 subunit Neighboring gene heparan-alpha-glucosaminide N-acetyltransferase-like protein (DUF1624) Neighboring gene transcription elongation factor Neighboring gene Zinc-binding ribosomal protein family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The plant NADPH oxidase RBOHD is required for microbiota homeostasis in leaves. Pfeilmeier S, et al. Nat Microbiol, 2021 Jul. PMID 34194036, Free PMC Article
    2. Vascular Bundles Mediate Systemic Reactive Oxygen Signaling during Light Stress. Zandalinas SI, et al. Plant Cell, 2020 Nov. PMID 32938754, Free PMC Article
    3. Antepenultimate residue at the C-terminus of NADPH oxidase RBOHD is critical for its function in the production of reactive oxygen species in Arabidopsis. Li QY, et al. J Zhejiang Univ Sci B, 2019 Sept.. PMID 31379142, Free PMC Article
    4. Local and Systemic Metabolic Responses during Light-Induced Rapid Systemic Signaling. Choudhury FK, et al. Plant Physiol, 2018 Dec. PMID 30279198, Free PMC Article
    5. A stress recovery signaling network for enhanced flooding tolerance in Arabidopsis thaliana. Yeung E, et al. Proc Natl Acad Sci U S A, 2018 Jun 26. PMID 29891679, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The phagocytosis oxidase/Bem1p domain-containing protein PB1CP negatively regulates the NADPH oxidase RBOHD in plant immunity.
      Title: The phagocytosis oxidase/Bem1p domain-containing protein PB1CP negatively regulates the NADPH oxidase RBOHD in plant immunity.
    2. Spatial regulation of RBOHD via AtECA4-mediated recycling and clathrin-mediated endocytosis contributes to ROS accumulation during salt stress response but not flg22-induced immune response.
      Title: Spatial regulation of RBOHD via AtECA4-mediated recycling and clathrin-mediated endocytosis contributes to ROS accumulation during salt stress response but not flg22-induced immune response.
    3. FLS2-RBOHD-PIF4 Module Regulates Plant Response to Drought and Salt Stress.
      Title: FLS2-RBOHD-PIF4 Module Regulates Plant Response to Drought and Salt Stress.
    4. The plant NADPH oxidase RBOHD is required for microbiota homeostasis in leaves.
      Title: The plant NADPH oxidase RBOHD is required for microbiota homeostasis in leaves.
    5. Vascular Bundles Mediate Systemic Reactive Oxygen Signaling during Light Stress.
      Title: Vascular Bundles Mediate Systemic Reactive Oxygen Signaling during Light Stress.
    6. CRK2 and C-terminal Phosphorylation of NADPH Oxidase RBOHD Regulate Reactive Oxygen Species Production in Arabidopsis.
      Title: CRK2 and C-terminal Phosphorylation of NADPH Oxidase RBOHD Regulate Reactive Oxygen Species Production in Arabidopsis.
    7. Persulfidation-based Modification of Cysteine Desulfhydrase and the NADPH Oxidase RBOHD Controls Guard Cell Abscisic Acid Signaling.
      Title: Persulfidation-based Modification of Cysteine Desulfhydrase and the NADPH Oxidase RBOHD Controls Guard Cell Abscisic Acid Signaling.
    8. Decrease of Arabidopsis PAO activity entails increased RBOH activity, ROS content and altered responses to Pseudomonas.
      Title: Decrease of Arabidopsis PAO activity entails increased RBOH activity, ROS content and altered responses to Pseudomonas.
    9. residue E919 is indispensable for RBOHD function in the microbe-associated molecular pattern-induced reactive oxygen species burst and stomatal closure
      Title: Antepenultimate residue at the C-terminus of NADPH oxidase RBOHD is critical for its function in the production of reactive oxygen species in Arabidopsis.
    10. data suggest that AtrbohD functions downstream of ROP2 to positively regulate the response to waterlogging stress in Arabidopsis.
      Title: AtrbohD functions downstream of ROP2 and positively regulates waterlogging response in Arabidopsis.
    Submit: New GeneRIF Correction See all GeneRIFs (38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_124165.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD(P)H oxidase H2O2-forming activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables NAD(P)H oxidase H2O2-forming activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within osmosensory signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within reactive oxygen species metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within reactive oxygen species metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    respiratory burst oxidase homologue D
    NP_199602.1
    • respiratory burst oxidase homologue D (RBOHD); FUNCTIONS IN: NAD(P)H oxidase activity; INVOLVED IN: oxygen and reactive oxygen species metabolic process, defense response to fungus, response to heat, defense response, negative regulation of programmed cell death; LOCATED IN: plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ferredoxin reductase-type FAD-binding domain (InterPro:IPR017927), Cytochrome b245, heavy chain (InterPro:IPR000778), EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-hand-like domain (InterPro:IPR011992), Ferric reductase-like transmembrane component, N-terminal (InterPro:IPR013130), NADPH oxidase Respiratory burst (InterPro:IPR013623), Ferric reductase, NAD binding (InterPro:IPR013121), EF-HAND 2 (InterPro:IPR018249), FAD-binding 8 (InterPro:IPR013112), Riboflavin synthase-like beta-barrel (InterPro:IPR017938); BEST Arabidopsis thaliana protein match is: NADPH/respiratory burst oxidase protein D (TAIR:AT5G51060.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19397041..19402061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124165.3 → NP_199602.1  respiratory burst oxidase homologue D [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199602.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81212, Q9FIJ0
      UniProtKB/TrEMBL
      A0A178U7Y0
      Conserved Domains (5) summary
      cd06186
      Location:619 → 921
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd00051
      Location:237 → 283
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01794
      Location:424 → 571
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam08030
      Location:736 → 903
      NAD_binding_6; Ferric reductase NAD binding domain
      pfam08414
      Location:161 → 255
      NADPH_Ox; Respiratory burst NADPH oxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FIJ0.1

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