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    SUVH1 SU(VAR)3-9 homolog 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830376, updated on 15-Oct-2023

    Summary

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    Gene symbol
    SUVH1
    Gene description
    SU(VAR)3-9 homolog 1
    Primary source
    Araport:AT5G04940
    Locus tag
    AT5G04940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MUG13.20; MUG13_20; SU(VAR)3-9 homolog 1
    Summary
    Encodes a SU(VAR)3-9 homolog, a SET domain protein. Known SET domain proteins are involved in epigenetic control of gene expression and act as histone methyltransferases. There are 10 SUVH genes in Arabidopsis and members of this subfamily of the SET proteins have an additional conserved SRA domain.
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    Genomic context

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    See SUVH1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (1454131..1457141, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Pol-like polyprotein/retrotransposon Neighboring gene uncharacterized protein Neighboring gene nicotianamine synthase 1 Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SUVH1, a Su(var)3-9 family member, promotes the expression of genes targeted by DNA methylation. Li S, et al. Nucleic Acids Res, 2016 Jan 29. PMID 26400170, Free PMC Article
    2. A DNA methylation reader complex that enhances gene transcription. Harris CJ, et al. Science, 2018 Dec 7. PMID 30523112, Free PMC Article
    3. A methylated-DNA-binding complex required for plant development mediates transcriptional activation of promoter methylated genes. Zhao QQ, et al. J Integr Plant Biol, 2019 Feb. PMID 30589221
    4. The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes. Baumbusch LO, et al. Nucleic Acids Res, 2001 Nov 1. PMID 11691919, Free PMC Article
    5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SUVH1 promotes the expression of genes targeted by DNA methylation.
      Title: SUVH1, a Su(var)3-9 family member, promotes the expression of genes targeted by DNA methylation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_120576.1
    NM_180436.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded methylated DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables histone methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within epigenetic regulation of gene expression TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    SU(VAR)3-9 homolog 1
    NP_196113.1
    • SU(VAR)3-9 homolog 1 (SUVH1); CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), SRA-YDG (InterPro:IPR003105), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Post-SET domain (InterPro:IPR003616), Pre-SET domain (InterPro:IPR007728); BEST Arabidopsis thaliana protein match is: SU(VAR)3-9 homolog 3 (TAIR:AT1G73100.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_850767.1
    • SU(VAR)3-9 homolog 1 (SUVH1); CONTAINS InterPro DOMAIN/s: SRA-YDG (InterPro:IPR003105), SET domain (InterPro:IPR001214), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Post-SET domain (InterPro:IPR003616), Pre-SET domain (InterPro:IPR007728); BEST Arabidopsis thaliana protein match is: SU(VAR)3-9 homolog 3 (TAIR:AT1G73100.1); Has 4151 Blast hits to 3953 proteins in 385 species: Archae - 0; Bacteria - 260; Metazoa - 2116; Fungi - 479; Plants - 984; Viruses - 5; Other Eukaryotes - 307 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      1454131..1457141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180436.2 → NP_850767.1  SU(VAR)3-9 homolog 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850767.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FF80
      UniProtKB/TrEMBL
      A0A178UBV2, A0A5S9Y224, C0SVN4
      Conserved Domains (3) summary
      smart00466
      Location:207 → 361
      SRA; SET and RING finger associated domain
      smart00317
      Location:495 → 639
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam05033
      Location:389 → 487
      Pre-SET; Pre-SET motif

    2. NM_120576.1 → NP_196113.1  SU(VAR)3-9 homolog 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196113.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FF80
      UniProtKB/TrEMBL
      A0A178UBV2, A0A5S9Y224, C0SVN4
      Conserved Domains (3) summary
      smart00466
      Location:207 → 361
      SRA; SET and RING finger associated domain
      smart00317
      Location:495 → 639
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam05033
      Location:389 → 487
      Pre-SET; Pre-SET motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FF80.1

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