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    FKD1 FORKED 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825505, updated on 7-Sep-2023

    Summary

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    Gene symbol
    FKD1
    Gene description
    FORKED 1
    Primary source
    Araport:AT3G63300
    Locus tag
    AT3G63300
    See related
    TAIR:AT3G63300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    FORKED 1; MAA21.9
    Summary
    Encodes a pleckstrin homology domain- and DUF828-containing protein. Mutants have defects in leaf vascular pattering, with vascular bundles that fail to meet distally in both the cotyledons and leaves. Necessary to the formation of the closed leaf vascular pattern characteristic of dicot leaves in response to auxin. Redundant with FKD2. FKD1 may influence PIN1 localization in an auxin dependent manner. proposed to be a key component of the auxin canalization pathway.
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    Genomic context

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    See FKD1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (23384988..23387842)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene NIMA-related kinase 4 Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene Bax inhibitor-1 family protein Neighboring gene Protein phosphatase 2C family protein Neighboring gene kinase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Localization of Arabidopsis FORKED1 to a RABA-positive compartment suggests a role in secretion. Prabhakaran Mariyamma N, et al. J Exp Bot, 2017 Jun 15. PMID 28575401, Free PMC Article
    2. FORKED1 encodes a PH domain protein that is required for PIN1 localization in developing leaf veins. Hou H, et al. Plant J, 2010 Sep. PMID 20626652
    3. The FORKED genes are essential for distal vein meeting in Arabidopsis. Steynen QJ, et al. Development, 2003 Oct. PMID 12925595
    4. Phosphoinositide-dependent regulation of VAN3 ARF-GAP localization and activity essential for vascular tissue continuity in plants. Naramoto S, et al. Development, 2009 May. PMID 19363154
    5. Members of the Arabidopsis FORKED1-LIKE gene family act to localize PIN1 in developing veins. Prabhakaran Mariyamma N, et al. J Exp Bot, 2018 Sep 14. PMID 29982821, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001340199.1
    NM_116195.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within auxin-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf vascular tissue pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem or xylem histogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within post-Golgi vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    colocalizes_with trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FORKED 1
    NP_001319826.1
    • FORKED 1 (FKD1); CONTAINS InterPro DOMAIN/s: Pleckstrin-like, plant (InterPro:IPR013666), Protein of unknown function DUF828 (InterPro:IPR008546); BEST Arabidopsis thaliana protein match is: Plant protein of unknown function (DUF828) with plant pleckstrin homology-like region (TAIR:AT3G22810.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_191889.2
    • FORKED 1 (FKD1); CONTAINS InterPro DOMAIN/s: Pleckstrin-like, plant (InterPro:IPR013666), Protein of unknown function DUF828 (InterPro:IPR008546); BEST Arabidopsis thaliana protein match is: Plant protein of unknown function (DUF828) with plant pleckstrin homology-like region (TAIR:AT3G22810.1); Has 742 Blast hits to 348 proteins in 78 species: Archae - 0; Bacteria - 118; Metazoa - 127; Fungi - 51; Plants - 226; Viruses - 0; Other Eukaryotes - 220 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      23384988..23387842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001340199.1 → NP_001319826.1  FORKED 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4J0Y8

    2. NM_116195.3 → NP_191889.2  FORKED 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191889.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8W4K5, Q9M1W0
      UniProtKB/TrEMBL
      A0A178VL38, A0A5S9XNA2
      Conserved Domains (2) summary
      pfam05703
      Location:30 → 336
      Auxin_canalis; Auxin canalisation
      pfam08458
      Location:379 → 484
      PH_2; Plant pleckstrin homology-like region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W4K5.1

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