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    ACA11 autoinhibited Ca2+-ATPase 11 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824900, updated on 7-Sep-2023

    Summary

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    Gene symbol
    ACA11
    Gene description
    autoinhibited Ca2+-ATPase 11
    Primary source
    Araport:AT3G57330
    Locus tag
    AT3G57330
    See related
    TAIR:AT3G57330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    autoinhibited Ca2+-ATPase 11
    Summary
    Lesion mimic phenotype when mutation in the gene is combined with a mutation in ACA4. Lesion mimic phenotype of double knockout can be suppressed by nutritional supplements that increase anion levels (e.g. 15 mM Nitrate, Chloride, or Phosphate)
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    Genomic context

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    See ACA11 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    8
    Sequence:
    Chromosome: 3; NC_003074.8 (21211014..21216836, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3E Neighboring gene DNA helicase INO80-like protein Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene threonine-tRNA ligase 2 Neighboring gene DnaJ heat shock amino-terminal domain protein (DUF1977) Neighboring gene ncRNA Neighboring gene Nucleoporin interacting component (Nup93/Nic96-like) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a calmodulin-regulated autoinhibited Ca2+-ATPase (ACA11) that is localized to vacuole membranes in Arabidopsis. Lee SM, et al. FEBS Lett, 2007 Aug 21. PMID 17662727
    2. Disruption of the vacuolar calcium-ATPases in Arabidopsis results in the activation of a salicylic acid-dependent programmed cell death pathway. Boursiac Y, et al. Plant Physiol, 2010 Nov. PMID 20837703, Free PMC Article
    3. Genomic comparison of P-type ATPase ion pumps in Arabidopsis and rice. Baxter I, et al. Plant Physiol, 2003 Jun. PMID 12805592, Free PMC Article
    4. Large-scale characterization of integral proteins from Arabidopsis vacuolar membrane by two-dimensional liquid chromatography. Szponarski W, et al. Proteomics, 2004 Feb. PMID 14760709
    5. Isolation of intact vacuoles and proteomic analysis of tonoplast from suspension-cultured cells of Arabidopsis thaliana. Shimaoka T, et al. Plant Cell Physiol, 2004 Jun. PMID 15215502

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A double disruption of Arabidopsis vacuolar pumps ACA4 and ACA11 results in a high frequency of apoptosis-like lesions.
      Title: Disruption of the vacuolar calcium-ATPases in Arabidopsis results in the activation of a salicylic acid-dependent programmed cell death pathway.
    2. ACA11 localizes to the vacuole membrane.
      Title: Identification of a calmodulin-regulated autoinhibited Ca2+-ATPase (ACA11) that is localized to vacuole membranes in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001339853.1
    NM_115593.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within defense response to bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic anion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    autoinhibited Ca2+-ATPase 11
    NP_191292.1
    • autoinhibited Ca2+-ATPase 11 (ACA11); FUNCTIONS IN: calcium-transporting ATPase activity, calmodulin binding; INVOLVED IN: defense response to bacterium, negative regulation of programmed cell death, anion homeostasis; LOCATED IN: plant-type vacuole membrane, chloroplast, plasma membrane, vacuole; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type, calcium-transporting, PMCA-type (InterPro:IPR006408), ATPase, P-type, H+ transporting proton pump (InterPro:IPR000695), ATPase, P-type cation-transporter, N-terminal (InterPro:IPR004014), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type phosphorylation site (InterPro:IPR018303), ATPase, P-type cation-transporter, C-terminal (InterPro:IPR006068); BEST Arabidopsis thaliana protein match is: autoinhibited Ca(2+)-ATPase, isoform 4 (TAIR:AT2G41560.1); Has 45492 Blast hits to 34566 proteins in 3220 species: Archae - 840; Bacteria - 31068; Metazoa - 4067; Fungi - 2704; Plants - 2054; Viruses - 3; Other Eukaryotes - 4756 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21211014..21216836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115593.7 → NP_191292.1  autoinhibited Ca2+-ATPase 11 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191292.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M2L4
      UniProtKB/TrEMBL
      A0A178VG68, A0A7G2ES56
      Conserved Domains (2) summary
      TIGR01517
      Location:57 → 1006
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12515
      Location:4 → 48
      CaATP_NAI; Ca2+-ATPase N terminal autoinhibitory domain

    2. NM_001339853.1 → NP_001326564.1  autoinhibited Ca2+-ATPase 11 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LPN7, A0A7G2ES56
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M2L4.1

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