SYP122 syntaxin of plants 122 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: SYP122
Gene description: syntaxin of plants 122
Primary source: Araport:AT3G52400
Locus tag: AT3G52400
See related: TAIR:AT3G52400
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATSYP122; syntaxin of plants 122
Summary: syntaxin protein, involved in the negative regulation of defense pathways such as programmed cell death, salicylic acid signalling pathway, jasmonic acid signalling pathway
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Genomic context

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See SYP122 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 2

Sequence:: Chromosome: 3; NC_003074.8 (19425632..19427230, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SYP121 and SYP122 are associated with different subsets of cargo proteins that are targeted for secretion at the plasma membrane.
Title: SNAREs SYP121 and SYP122 Mediate the Secretion of Distinct Cargo Subsets.
The domain of SEC11 that bound the SYP121 N terminus was itself able to block secretory traffic in the wild type and syp122 but not in syp121 mutant Arabidopsis.
Title: Binding of SEC11 indicates its role in SNARE recycling after vesicle fusion and identifies two pathways for vesicular traffic to the plasma membrane.
SYP122 may have a general function in secretion and a role in cell wall deposition, while its homolog PEN1 appears to have a basal function in secretion and a specialized defense-related function
Title: The PEN1 syntaxin defines a novel cellular compartment upon fungal attack and is required for the timely assembly of papillae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_115100.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNAP receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to fungus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular protein transport	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within jasmonic acid mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within membrane fusion	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of cellular defense response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein targeting to membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of plant-type hypersensitive response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within salicylic acid mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: syntaxin of plants 122

NP_190808.1

syntaxin of plants 122 (SYP122); FUNCTIONS IN: SNAP receptor activity; INVOLVED IN: in 9 processes; LOCATED IN: plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Target SNARE coiled-coil domain (InterPro:IPR000727), t-SNARE (InterPro:IPR010989), Syntaxin/epimorphin, conserved site (InterPro:IPR006012), Syntaxin, N-terminal (InterPro:IPR006011); BEST Arabidopsis thaliana protein match is: syntaxin of plants 121 (TAIR:AT3G11820.2); Has 2448 Blast hits to 2448 proteins in 275 species: Archae - 5; Bacteria - 34; Metazoa - 1056; Fungi - 527; Plants - 461; Viruses - 0; Other Eukaryotes - 365 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

19425632..19427230 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_115100.3 → NP_190808.1 syntaxin of plants 122 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_190808.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SUJ2, Q9SVC2

UniProtKB/TrEMBL

A0A178VEE7, A0A5S9XKX9

Conserved Domains (2) summary

pfam00804
Location:43 → 248

Syntaxin

cl22856
Location:216 → 282

SNARE; SNARE motif