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    DSPTP1 dual specificity protein phosphatase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821941, updated on 15-Oct-2023

    Summary

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    Gene symbol
    DSPTP1
    Gene description
    dual specificity protein phosphatase 1
    Primary source
    Araport:AT3G23610
    Locus tag
    AT3G23610
    See related
    TAIR:AT3G23610
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    dual specificity protein phosphatase 1
    Summary
    Encodes a dual specificity protein phosphatase whose activity is modulated by CaM binding.
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    Genomic context

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    See DSPTP1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (8477800..8479877)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Ubiquitin-like superfamily protein Neighboring gene ncRNA Neighboring gene Ribosomal RNA processing Brix domain protein Neighboring gene isopentenyltransferase 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtDsPTP1 acts as a negative regulator in osmotic stress signalling during Arabidopsis seed germination and seedling establishment. Liu R, et al. J Exp Bot, 2015 Mar. PMID 25540435, Free PMC Article
    2. Identification of a dual-specificity protein phosphatase that inactivates a MAP kinase from Arabidopsis. Gupta R, et al. Plant J, 1998 Dec. PMID 10036776
    3. Regulation of the dual specificity protein phosphatase, DsPTP1, through interactions with calmodulin. Yoo JH, et al. J Biol Chem, 2004 Jan 9. PMID 14570888
    4. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DsPTP1 acts as a negative regulator in osmotic stress signalling during seed germination and seedling growth.
      Title: AtDsPTP1 acts as a negative regulator in osmotic stress signalling during Arabidopsis seed germination and seedling establishment.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001125211.3
    NM_001203026.1
    NM_001338651.1
    NM_113265.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in cellular response to cold NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    NOT involved_in cellular response to heat NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    NOT involved_in cellular response to salt stress NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in response to wounding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein phosphatase 1
    NP_001118683.1
    • dual specificity protein phosphatase 1 (DSPTP1); CONTAINS InterPro DOMAIN/s: Dual-specific/protein-tyrosine phosphatase, conserved region (InterPro:IPR000387), Dual specificity phosphatase (InterPro:IPR020417), Dual specificity phosphatase, catalytic domain (InterPro:IPR000340), Dual specificity phosphatase, subgroup, catalytic domain (InterPro:IPR020422); BEST Arabidopsis thaliana protein match is: MAPK phosphatase 2 (TAIR:AT3G06110.3); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_001189955.1
    • dual specificity protein phosphatase 1 (DSPTP1); CONTAINS InterPro DOMAIN/s: Dual specificity phosphatase (InterPro:IPR020417), Dual-specific/protein-tyrosine phosphatase, conserved region (InterPro:IPR000387), Dual specificity phosphatase, catalytic domain (InterPro:IPR000340), Dual specificity phosphatase, subgroup, catalytic domain (InterPro:IPR020422); BEST Arabidopsis thaliana protein match is: MAPK phosphatase 2 (TAIR:AT3G06110.3).
    NP_189003.1
    • dual specificity protein phosphatase 1 (DSPTP1); CONTAINS InterPro DOMAIN/s: Dual-specific/protein-tyrosine phosphatase, conserved region (InterPro:IPR000387), Dual specificity phosphatase (InterPro:IPR020417), Dual specificity phosphatase, catalytic domain (InterPro:IPR000340), Dual specificity phosphatase, subgroup, catalytic domain (InterPro:IPR020422); BEST Arabidopsis thaliana protein match is: MAPK phosphatase 2 (TAIR:AT3G06110.3); Has 4429 Blast hits to 4425 proteins in 398 species: Archae - 22; Bacteria - 149; Metazoa - 2258; Fungi - 464; Plants - 388; Viruses - 233; Other Eukaryotes - 915 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      8477800..8479877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001338649.1 → NP_001326887.1  dual specificity protein phosphatase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LQM6, A0A5S9XF87, A0A654FA08
      Conserved Domains (1) summary
      cd14498
      Location:51 → 184
      DSP; dual-specificity phosphatase domain

    2. NM_001338650.1 → NP_001326888.1  dual specificity protein phosphatase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LQM7, A0A5S9XF87, A0A654FA08

    3. NM_001125211.3 → NP_001118683.1  dual specificity protein phosphatase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118683.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XF87, A0A654FA08
      Conserved Domains (1) summary
      cd14498
      Location:51 → 184
      DSP; dual-specificity phosphatase domain

    4. NM_001338651.1 → NP_001326889.1  dual specificity protein phosphatase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LQM8

    5. NM_113265.1 → NP_189003.1  dual specificity protein phosphatase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189003.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3H4F5, F4J449, Q9LUG6, Q9ZR37
      UniProtKB/TrEMBL
      A0A5S9XF87, A0A654FA08
      Conserved Domains (1) summary
      cd14498
      Location:51 → 184
      DSP; dual-specificity phosphatase domain

    6. NM_001203026.1 → NP_001189955.1  dual specificity protein phosphatase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189955.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XF87, A0A654FA08
      Conserved Domains (2) summary
      COG2453
      Location:53 → 191
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      cd00127
      Location:51 → 186
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZR37.1

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