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    FACE2 farnesylated protein-converting enzyme 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818203, updated on 7-Sep-2023

    Summary

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    Gene symbol
    FACE2
    Gene description
    farnesylated protein-converting enzyme 2
    Primary source
    Araport:AT2G36305
    Locus tag
    AT2G36305
    See related
    TAIR:AT2G36305
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA FARNESYLATED PROTEIN-CONVERTING ENZYME 2; ARABIDOPSIS THALIANA FARNESYLATED PROTEIN-CONVERTING ENZYME-2; ATFACE-2; ATFACE2; ATRCE1; farnesylated protein-converting enzyme 2; RAS-CONVERTING ENZYME 1; RCE1
    Summary
    Encodes an endoprotease involved in the cleavage of prenylated CaaX-box proteins. In vitro, it can cleave a farnesylated tetrapeptide and it can promote membrane-localization of a farnesylated GFP:AtROP9 protein when both are expressed in yeast.
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    Genomic context

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    See FACE2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (15214386..15216613)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Integral membrane Yip1 family protein Neighboring gene ncRNA Neighboring gene uridine-ribohydrolase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtFACE-2, a functional prenylated protein protease from Arabidopsis thaliana related to mammalian Ras-converting enzymes. Cadiñanos J, et al. J Biol Chem, 2003 Oct 24. PMID 12928436
    2. Functional analysis of Arabidopsis postprenylation CaaX processing enzymes and their function in subcellular protein targeting. Bracha-Drori K, et al. Plant Physiol, 2008 Sep. PMID 18641086, Free PMC Article
    3. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_179931.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within CAAX-box protein maturation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in CAAX-box protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    farnesylated protein-converting enzyme 2
    NP_850262.2
    • farnesylated protein-converting enzyme 2 (FACE2); CONTAINS InterPro DOMAIN/s: Abortive infection protein (InterPro:IPR003675); Has 361 Blast hits to 361 proteins in 186 species: Archae - 0; Bacteria - 39; Metazoa - 116; Fungi - 118; Plants - 43; Viruses - 0; Other Eukaryotes - 45 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      15214386..15216613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336593.1 → NP_001325233.1  farnesylated protein-converting enzyme 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VXU6, A0A1P8B2N0

    2. NM_179931.4 → NP_850262.2  farnesylated protein-converting enzyme 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850262.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q70VU9, Q8GW19
      UniProtKB/TrEMBL
      A0A178VX83
      Conserved Domains (1) summary
      pfam02517
      Location:151 → 257
      Abi; CAAX protease self-immunity
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GW19.2

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