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    MEE22 maternal effect embryo arrest 22 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818043, updated on 7-Sep-2023

    Summary

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    Gene symbol
    MEE22
    Gene description
    maternal effect embryo arrest 22
    Primary source
    Araport:AT2G34780
    Locus tag
    AT2G34780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    EMB1611; EMBRYO DEFECTIVE 1611; F19I3.1; F19I3_1; MATERNAL EFFECT EMBRYO ARREST 22
    Summary
    Encodes a novel protein of unknown function that is essential for embryonic development. Severe loss of function alleles are embryo lethal. Analysis of a partial loss of function allele indicates a role for EMB1611 in regulation of endoreduplication and maintenance of meristem cell fate. It appears to be required for maintaining the CLV-WUS regulatory pathway.
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    Genomic context

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    See MEE22 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (14668440..14673904)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene fatty acid hydroxylase 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene FAD-binding Berberine family protein Neighboring gene FAD-binding Berberine family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The essential gene EMB1611 maintains shoot apical meristem function during Arabidopsis development. Leasure CD, et al. Plant J, 2009 Feb. PMID 18980659
    2. Genetic and molecular identification of genes required for female gametophyte development and function in Arabidopsis. Pagnussat GC, et al. Development, 2005 Feb. PMID 15634699
    3. Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method. Bach-Pages M, et al. Biomolecules, 2020 Apr 24. PMID 32344669, Free PMC Article
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EMB1611 is required for maintenance of the stem cell regulatory pathway in the shoot meristem.
      Title: The essential gene EMB1611 maintains shoot apical meristem function during Arabidopsis development.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001202750.1
    NM_001336527.1
    NM_001336528.1
    NM_179906.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within maintenance of meristem identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meristem structural organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    maternal effect embryo arrest 22
    NP_001189679.1
    • MATERNAL EFFECT EMBRYO ARREST 22 (MEE22); INVOLVED IN: negative regulation of DNA endoreduplication, meristem structural organization, embryo development ending in seed dormancy, maintenance of meristem identity; LOCATED IN: cellular_component unknown; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages.
    NP_850237.1
    • MATERNAL EFFECT EMBRYO ARREST 22 (MEE22); Has 114610 Blast hits to 64620 proteins in 2807 species: Archae - 1395; Bacteria - 19220; Metazoa - 50238; Fungi - 9135; Plants - 5590; Viruses - 506; Other Eukaryotes - 28526 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      14668440..14673904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202750.1 → NP_001189679.1  maternal effect embryo arrest 22 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189679.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4IIV6
      Conserved Domains (1) summary
      pfam14735
      Location:158 → 354
      HAUS4; HAUS augmin-like complex subunit 4

    2. NM_179906.3 → NP_850237.1  maternal effect embryo arrest 22 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850237.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9X4I0, A0A654F087, F4IIV5
      Conserved Domains (2) summary
      pfam08614
      Location:41 → 161
      ATG16; Autophagy protein 16 (ATG16)
      pfam14735
      Location:219 → 415
      HAUS4; HAUS augmin-like complex subunit 4

    3. NM_001336527.1 → NP_001324225.1  maternal effect embryo arrest 22 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4IIV6

    4. NM_001336528.1 → NP_001324226.1  maternal effect embryo arrest 22 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4IIV6
    Nucleotide Protein
    Heading Accession and Version

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