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    caspbl caspase b, like [ Danio rerio (zebrafish) ]

    Gene ID: 566185, updated on 11-Apr-2024

    Summary

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    Official Symbol
    caspblprovided by ZNC
    Official Full Name
    caspase b, likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090311-53
    See related
    Ensembl:ENSDARG00000094433 AllianceGenome:ZFIN:ZDB-GENE-090311-53
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    caspb; casp19b; si:ch211-15j1.6
    Summary
    Predicted to enable cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Predicted to act upstream of or within proteolysis. Predicted to be active in cytoplasm. Orthologous to several human genes including CASP1 (caspase 1); CASP4 (caspase 4); and CASP5 (caspase 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See caspbl in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (58105742..58115334, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (57370060..57379635, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene si:ch211-114l13.13 Neighboring gene NLR family, CARD domain containing 10 Neighboring gene si:ch211-114l13.1 Neighboring gene si:ch211-15j1.5 Neighboring gene si:ch211-15j1.4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish. Yang D, et al. Nat Commun, 2018 Aug 3. PMID 30076291, Free PMC Article
    2. Characterization of the caspase family in zebrafish. Spead O, et al. PLoS One, 2018. PMID 29791492, Free PMC Article
    3. Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome. Rajshekar S, et al. Elife, 2018 Nov 28. PMID 30484769, Free PMC Article
    4. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NLRP1 inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    caspase b, like; uncharacterized protein LOC566185
    Names
    caspase 19b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145592.1 → NP_001139064.1  caspase b, like

      Status: PROVISIONAL

      Source sequence(s)
      BX469930, BX927298
      UniProtKB/TrEMBL
      A0A8M1NTC1, B8A526, F1QBB1
      Related
      ENSDARP00000120747.3, ENSDART00000134949.3
      Conserved Domains (2) summary
      cd00032
      Location:167 → 406
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08321
      Location:5 → 84
      Pyrin_ASC-like; Pyrin Death Domain found in ASC

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      58105742..58115334 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160202.4 → XP_005160259.1  uncharacterized protein LOC566185 isoform X1

      See identical proteins and their annotated locations for XP_005160259.1

      UniProtKB/TrEMBL
      A0A2U9DQQ6
      Conserved Domains (2) summary
      cd00032
      Location:153 → 392
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08321
      Location:5 → 84
      Pyrin_ASC-like; Pyrin Death Domain found in ASC
    Nucleotide Protein Strain
    Heading Accession and Version

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