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    Nup133 Nucleoporin 133kD [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42680, updated on 10-May-2024

    Summary

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    Official Symbol
    Nup133provided by FlyBase
    Official Full Name
    Nucleoporin 133kDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039004
    Locus tag
    Dmel_CG6958
    See related
    AllianceGenome:FB:FBgn0039004
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6958; Dmel\CG6958; Nup 133; nup133
    Summary
    Predicted to be a structural constituent of nuclear pore. Predicted to be involved in poly(A)+ mRNA export from nucleus; protein import into nucleus; and transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Predicted to be part of nuclear pore outer ring. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome and nephrotic syndrome type 18. Orthologous to human NUP133 (nucleoporin 133). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See Nup133 in Genome Data Viewer
    Location:
    94C1-94C1; 3-76 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22690607..22694772)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18516329..18520494)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene wolfram syndrome 1 Neighboring gene cardinal Neighboring gene Cytochrome P450 6d4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel method to detect proteins evolving at correlated rates: identifying new functional relationships between coevolving proteins. Clark NL, et al. Mol Biol Evol, 2010 May. PMID 20044587, Free PMC Article
    2. Genetic Analyses of Elys Mutations in Drosophila Show Maternal-Effect Lethality and Interactions with Nucleoporin Genes. Hirai K, et al. G3 (Bethesda), 2018 Jul 2. PMID 29773558, Free PMC Article
    3. Pervasive adaptive evolution among interactors of the Drosophila hybrid inviability gene, Nup96. Presgraves DC, et al. Mol Biol Evol, 2007 Jan. PMID 17056646
    4. Specific nucleoporin requirement for Smad nuclear translocation. Chen X, et al. Mol Cell Biol, 2010 Aug. PMID 20547758, Free PMC Article
    5. Drosophila ELYS regulates Dorsal dynamics during development. Mehta SJK, et al. J Biol Chem, 2020 Feb 21. PMID 31941789, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of nuclear pore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of nuclear pore outer ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore outer ring ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nucleoporin 133kD
    Names
    CG6958-PA
    Nup133-PA
    nucleoporin 133

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22690607..22694772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142823.3 → NP_651080.2  nucleoporin 133kD [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651080.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86PB8, Q961A9, Q9VCW3
      UniProtKB/TrEMBL
      A1YK77, A1YK80, A1YK85, A1YK86
      Related
      FBpp0083695
      Conserved Domains (2) summary
      pfam03177
      Location:767 → 1122
      Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal
      pfam08801
      Location:87 → 489
      Nucleoporin_N; Nup133 N terminal like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1YK77 A1YK77
    A1YK78 A1YK78
    A1YK79 A1YK79
    A1YK80 A1YK80
    A1YK81 A1YK81
    A1YK82 A1YK82
    A1YK83 A1YK83
    A1YK85 A1YK85
    A1YK86 A1YK86
    Q9VCW3.2 Q9VCW3

    Gene LinkOut

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