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    Setd3 SET domain containing 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31638, updated on 26-Apr-2024

    Summary

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    Official Symbol
    Setd3provided by FlyBase
    Official Full Name
    SET domain containing 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0052732
    Locus tag
    Dmel_CG32732
    See related
    AllianceGenome:FB:FBgn0052732
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12542; CG3042; CG32732; Dmel\CG32732; dSETD3; SETD3
    Summary
    Enables protein-L-histidine N-tele-methyltransferase activity. Involved in actin modification and peptidyl-histidine methylation. Located in cytoplasm and nucleus. Is expressed in adult head and spermatozoon. Orthologous to human SETD3 (SET domain containing 3, actin histidine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    6E3-6E4; 1-18 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6958032..6968750, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6852065..6862783, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phenotypic characterization of SETD3 knockout Drosophila. Tiebe M, et al. PLoS One, 2018. PMID 30067821, Free PMC Article
    2. SETD3 protein is the actin-specific histidine N-methyltransferase. Kwiatkowski S, et al. Elife, 2018 Dec 11. PMID 30526847, Free PMC Article
    3. Multilocus patterns of nucleotide variability and the demographic and selection history of Drosophila melanogaster populations. Haddrill PR, et al. Genome Res, 2005 Jun. PMID 15930491, Free PMC Article
    4. Comparative genomic analysis of SET domain family reveals the origin, expansion, and putative function of the arthropod-specific SmydA genes as histone modifiers in insects. Jiang F, et al. Gigascience, 2017 Jun 1. PMID 28444351, Free PMC Article
    5. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Schotta G, et al. Genes Dev, 2004 Jun 1. PMID 15145825, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone H3K36 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K4 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-L-histidine N-tele-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-L-histidine N-tele-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-histidine methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-lysine monomethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-lysine trimethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SET domain containing 3
    Names
    CG32732-PA
    Setd3-PA
    NP_727144.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6958032..6968750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167100.3 → NP_727144.1  SET domain containing 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727144.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W3U1
      Related
      FBpp0070998
      Conserved Domains (2) summary
      pfam09273
      Location:400 → 524
      Rubis-subs-bind; Rubisco LSMT substrate-binding
      cd19176
      Location:119 → 378
      SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3U1.2 Q9W3U1

    Gene LinkOut

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