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    set-27 protein-histidine N-methyltransferase [ Caenorhabditis elegans ]

    Gene ID: 190607, updated on 5-May-2024

    Summary

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    Gene symbol
    set-27
    Gene description
    protein-histidine N-methyltransferase
    Primary source
    WormBase:WBGene00022173
    Locus tag
    CELE_Y71H2AM.8
    See related
    AllianceGenome:WB:WBGene00022173
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histone methyltransferase activity (H3-K36 specific); histone methyltransferase activity (H3-K4 specific); and transcription coactivator activity. Predicted to be involved in peptidyl-lysine methylation and positive regulation of transcription by RNA polymerase II. Is expressed in germ line and muscle cell. Orthologous to human SETD3 (SET domain containing 3, actin histidine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (2700937..2707846)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene EF-hand domain-containing protein Neighboring gene CX domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Proton-coupled zinc antiporter SLC30A9, mitochondrial Neighboring gene Transmembrane protein family 132 middle domain-containing protein Neighboring gene tRNA-Pro Neighboring gene Peptidase M20 dimerization domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development. Andersen EC, et al. Development, 2007 Aug. PMID 17634190
    2. Epigenetics in C. elegans: facts and challenges. Wenzel D, et al. Genesis, 2011 Aug. PMID 21538806
    3. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    4. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
    5. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables histone H3K36 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K4 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-lysine monomethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-lysine trimethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein-histidine N-methyltransferase
    NP_497604.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2700937..2707846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065203.4 → NP_497604.2  protein-histidine N-methyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497604.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BL48
      Conserved Domains (1) summary
      cd19176
      Location:76 → 360
      SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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