si:dkey-33c9.6 si:dkey-33c9.6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: si:dkey-33c9.6provided by ZNC
Official Full Name: si:dkey-33c9.6provided by ZNC
Primary source: ZFIN:ZDB-GENE-130530-592
See related: Ensembl:ENSDARG00000036420 AllianceGenome:ZFIN:ZDB-GENE-130530-592
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zmp:0000000589
Summary: Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within positive regulation of GTPase activity and signal transduction. Predicted to be located in axon and dendritic spine. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

See si:dkey-33c9.6 in Genome Data Viewer

Location:: chromosome: 7

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (20393283..20422682)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (20132258..20170714)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G41839 (e-PCR)
- UniSTS:23082

G41742 (e-PCR)
- UniSTS:23083

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: active breakpoint cluster region-related protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

20393283..20422682

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021477768.1 → XP_021333443.1 active breakpoint cluster region-related protein-like

UniProtKB/TrEMBL

A0A8M9Q2A7, E7F9C1

Related

ENSDARP00000142678.1, ENSDART00000173809.2

Conserved Domains (4) summary

smart00325
Location:71 → 280

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd04387
Location:623 → 811

RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...

cl14603
Location:494 → 604

C2; C2 domain

cl17171
Location:296 → 452

PH-like; Pleckstrin homology-like domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394685.1 Reference GRCz11 ALT_DRER_TU_1

Range

6599..35188

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021471891.1 → XP_021327566.1 active breakpoint cluster region-related protein-like

UniProtKB/TrEMBL

A0A8M9PYZ5

Conserved Domains (4) summary

smart00325
Location:71 → 281

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cl02570
Location:624 → 812

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl14603
Location:495 → 605

C2; C2 domain

cl17171
Location:297 → 453

PH-like; Pleckstrin homology-like domain