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    si:dkey-46g23.2 si:dkey-46g23.2 [ Danio rerio (zebrafish) ]

    Gene ID: 793100, updated on 27-Mar-2024

    Summary

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    Official Symbol
    si:dkey-46g23.2provided by ZNC
    Official Full Name
    si:dkey-46g23.2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070705-476
    See related
    Ensembl:ENSDARG00000115817 AllianceGenome:ZFIN:ZDB-GENE-070705-476
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; background diabetic retinopathy; multiple sclerosis; neurodegenerative disease (multiple); and obstructive lung disease. Orthologous to several human genes including PZP (PZP alpha-2-macroglobulin like) and A2M (alpha-2-macroglobulin). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See si:dkey-46g23.2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (3386221..3401714, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (3603970..3616125, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 184Bb, duplicate 1 Neighboring gene trinucleotide repeat containing adaptor 6Bb.1 Neighboring gene zgc:171446 Neighboring gene zgc:171445

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dynamic evolutionary pattern of alpha2-macroglobulin in a model organism, the zebrafish (Danio rerio). Padhi A, et al. Mol Immunol, 2008 Jun. PMID 18485482
    2. Analysis of protein expression in developmental toxicity induced by MeHg in zebrafish. Cuello S, et al. Analyst, 2012 Nov 21. PMID 23014190
    3. A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery. Tiefenbach J, et al. PLoS One, 2010 Mar 22. PMID 20339547, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-2-macroglobulin-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      3386221..3401714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021472100.1 → XP_021327775.1  alpha-2-macroglobulin-like protein 1

      UniProtKB/TrEMBL
      A0A8M9Q2V0
      Related
      ENSDARP00000047864.7, ENSDART00000047865.9
      Conserved Domains (5) summary
      cd02897
      Location:871 → 1146
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:653 → 741
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:47 → 138
      A2M_N; MG2 domain
      pfam07677
      Location:1265 → 1354
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:380 → 528
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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