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    BLB1 major histocompatibility complex Y, class II beta BLB1 [ Gallus gallus (chicken) ]

    Gene ID: 693256, updated on 6-Jun-2024

    Summary

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    Official Symbol
    BLB1provided by CGNC
    Official Full Name
    major histocompatibility complex Y, class II beta BLB1provided by CGNC
    Primary source
    CGNC:54366
    See related
    Ensembl:ENSGALG00010002991
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    B-LB; B-LB21; GSP-BLB1
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    Genomic context

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    See BLB1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 16 NC_052547.1 (2185532..2187356, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 16 NC_052588.1 (1086656..1088481, complement)

    Chromosome 16 - NC_052547.1Genomic Context describing neighboring genes Neighboring gene BG antigen 1, MHCB region Neighboring gene c-type lectin like 1, MHCB region Neighboring gene c-type lectin like 2, MHCB region Neighboring gene TAP binding protein Neighboring gene Major histocompatibility complex class II beta chain BLB2, (similar to HLA class II, D beta chain)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of B-L beta-chain gene expression in two chicken cDNA libraries. Pharr GT, et al. Immunogenetics, 1993. PMID 8428771
    2. Character of chicken polymorphic major histocompatibility complex class II alleles of 3 Chinese local breeds. Chen F, et al. Poult Sci, 2012 May. PMID 22499866
    3. Characterization of genetic polymorphism of novel MHC B-LB II alleles in Chinese indigenous chickens. Xu R, et al. J Genet Genomics, 2007 Feb. PMID 17469783
    4. Chicken MHC class I and II gene effects on antibody response kinetics in adult chickens. Zhou H, et al. Immunogenetics, 2003 Jun. PMID 12743657
    5. Three new MHC haplotypes in broiler breeder chickens. Livant EJ, et al. Anim Genet, 2001 Jun. PMID 11493260

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptide antigen assembly with MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Major histocompatibility complex class II beta chain BLB1, (similar to HLA class II, D beta chain); major histocompatibility complex class II beta chain BLB1, (similar to HLA class II, D beta chain)
    Names
    B-L beta minor
    BLB major
    Bl-Beta II protein
    MHC class II B-L beta chain
    MHC class II antigen B-F minor heavy chain
    MHC class II antigen beta chain
    MHC class II beta 1 domain
    MHC class II beta chain 1
    Major histocompatibility complex class II beta chain BLB1
    major histocompatibility complex class II B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044679.2 → NP_001038144.2  Major histocompatibility complex class II beta chain BLB1, (similar to HLA class II, D beta chain) precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000283
      UniProtKB/TrEMBL
      A0A1D5PLI8
      Related
      ENSGALP00010004246.1, ENSGALT00010006984.1
      Conserved Domains (2) summary
      cd05766
      Location:123 → 216
      IgC_MHC_II_beta; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain
      pfam00969
      Location:39 → 113
      MHC_II_beta; Class II histocompatibility antigen, beta domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052547.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      2185532..2187356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015294994.4 → XP_015150480.1  major histocompatibility complex class II beta chain BLB1, (similar to HLA class II, D beta chain) isoform X1

      UniProtKB/TrEMBL
      A0A1D5P3L9, A5HUL2, B5BSJ6, B6RCP2, F1C6U2, F1NSZ6
      Related
      ENSGALP00010004245.1, ENSGALT00010006982.1
      Conserved Domains (2) summary
      cd05766
      Location:123 → 216
      IgC_MHC_II_beta; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain
      pfam00969
      Location:39 → 113
      MHC_II_beta; Class II histocompatibility antigen, beta domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052588.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      1086656..1088481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046928562.1 → XP_046784518.1  major histocompatibility complex class II beta chain BLB1, (similar to HLA class II, D beta chain) isoform X1

      UniProtKB/TrEMBL
      A0A1D5P3L9, A5HUL2, B5BSJ6, B6RCP2, F1C6U2, F1NSZ6
    Nucleotide Protein Strain
    Heading Accession and Version

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