Pabpc6 poly(A) binding protein, cytoplasmic 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pabpc6provided by MGI
Official Full Name: poly(A) binding protein, cytoplasmic 6provided by MGI
Primary source: MGI:MGI:1914793
See related: Ensembl:ENSMUSG00000046173 AllianceGenome:MGI:1914793
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pabpc3; 4932702K14Rik
Summary: Predicted to enable RNA binding activity and protein C-terminus binding activity. Predicted to be located in cell leading edge and cytoplasmic ribonucleoprotein granule. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Is expressed in several structures, including alimentary system; brain; nose; urinary system; and vibrissa. Orthologous to human PABPC1 (poly(A) binding protein cytoplasmic 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 17 A1; 17 7.47 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (9885426..9888633, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (9666497..9669704, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intronless Pabpc6 encodes a testis-specific, cytoplasmic poly(A)-binding protein but is dispensable for spermatogenesis in the mousedagger.
Title: Intronless Pabpc6 encodes a testis-specific, cytoplasmic poly(A)-binding protein but is dispensable for spermatogenesis in the mouse†.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

Pabpc3 (e-PCR), detects polymorphism
- UniSTS:478983

AI428050 (e-PCR)
- UniSTS:180959

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(U) RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: poly(A) binding protein, cytoplasmic 3

Names: poly A binding protein, cytoplasmic 1 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163836.1 → NP_001157308.1 poly(A) binding protein, cytoplasmic 3

See identical proteins and their annotated locations for NP_001157308.1

Status: VALIDATED

Source sequence(s)

AC134446, AK016578, AK029765

Consensus CDS

CCDS49946.1

UniProtKB/TrEMBL

Q9D4E6

Related

ENSMUSP00000050792.3, ENSMUST00000057190.4

Conserved Domains (6) summary

TIGR01628
Location:11 → 622

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12378
Location:12 → 91

RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins

cd12379
Location:97 → 172

RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins

cd12380
Location:190 → 269

RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins

cd12381
Location:303 → 380

RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins

pfam00658
Location:554 → 621

PABP; Poly-adenylate binding protein, unique domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

9885426..9888633 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_026226.2: Suppressed sequence

Description

NM_026226.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
NR_003636.1: Suppressed sequence

Description

NR_003636.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.