Apol11a apolipoprotein L 11a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Apol11aprovided by MGI
Official Full Name: apolipoprotein L 11aprovided by MGI
Primary source: MGI:MGI:3649094
See related: Ensembl:ENSMUSG00000091650 AllianceGenome:MGI:3649094
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EG626615
Summary: Predicted to enable chloride channel activity and lipid binding activity. Predicted to be located in extracellular space and intracellular membrane-bounded organelle. Predicted to be part of high-density lipoprotein particle and very-low-density lipoprotein particle. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and schizophrenia. Orthologous to several human genes including APOL1 (apolipoprotein L1); APOL2 (apolipoprotein L2); and APOL3 (apolipoprotein L3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 15 D3; 15 36.4 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (77392329..77402074)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (77508129..77517874)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chloride channel activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apolipoprotein L 11a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.