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    pcgf5a polycomb group ring finger 5a [ Danio rerio (zebrafish) ]

    Gene ID: 562327, updated on 27-Mar-2024

    Summary

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    Official Symbol
    pcgf5aprovided by ZNC
    Official Full Name
    polycomb group ring finger 5aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080723-33
    See related
    Ensembl:ENSDARG00000071007 AllianceGenome:ZFIN:ZDB-GENE-080723-33
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:194668; zgc:194700
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in histone H2A-K119 monoubiquitination and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of PRC1 complex. Is expressed in eye; gonad; and muscle. Orthologous to human PCGF5 (polycomb group ring finger 5). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See pcgf5a in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (23433603..23446686, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (23411182..23426662, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909037 Neighboring gene uncharacterized LOC103909038 Neighboring gene ankyrin repeat domain 1a (cardiac muscle) Neighboring gene kinesin family member 20Ba

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The Polycomb Group Protein Pcgf1 Is Dispensable in Zebrafish but Involved in Early Growth and Aging. Dupret B, et al. PLoS One, 2016. PMID 27442247, Free PMC Article
    2. Gene expression profile of a selection of Polycomb Group genes during zebrafish embryonic and germ line development. Chrispijn ND, et al. PLoS One, 2018. PMID 29985950, Free PMC Article
    3. Temporal and spatial expression of fgfbp genes in zebrafish. Li Y, et al. Gene, 2018 Jun 15. PMID 29551495
    4. The zebrafish genes encoding the Polycomb repressive complex (PRC) 1. Le Faou P, et al. Gene, 2011 Apr 1. PMID 21195142
    5. Characterization of zebrafish (Danio rerio) muscle ankyrin repeat proteins reveals their conserved response to endurance exercise. Boskovic S, et al. PLoS One, 2018. PMID 30252882, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PcG protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polycomb group RING finger protein 5-A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128712.1 → NP_001122184.1  polycomb group RING finger protein 5-A

      See identical proteins and their annotated locations for NP_001122184.1

      Status: PROVISIONAL

      Source sequence(s)
      BC163702
      UniProtKB/Swiss-Prot
      B3DK16
      Related
      ENSDARP00000095486.2, ENSDART00000104715.4
      Conserved Domains (2) summary
      pfam00097
      Location:18 → 56
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam16207
      Location:155 → 228
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      23433603..23446686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017351660.2 → XP_017207149.1  polycomb group RING finger protein 5-A isoform X1

      UniProtKB/Swiss-Prot
      B3DK16
      Conserved Domains (2) summary
      pfam00097
      Location:18 → 56
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam16207
      Location:155 → 228
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394988.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      450330..464689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395331.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      15092..27567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B3DK16.1 GenPept UniProtKB/Swiss-Prot:B3DK16

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