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    myo5aa myosin VAa [ Danio rerio (zebrafish) ]

    Gene ID: 562188, updated on 27-Mar-2024

    Summary

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    Official Symbol
    myo5aaprovided by ZNC
    Official Full Name
    myosin VAaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041027-2
    See related
    Ensembl:ENSDARG00000061635 AllianceGenome:ZFIN:ZDB-GENE-041027-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    myo5a; si:dkey-266j9.1
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and vesicle transport along actin filament. Predicted to be part of myosin complex. Predicted to be active in actin cytoskeleton; cytoplasm; and vesicle. Is expressed in central nervous system; dorsolateral placode; intestine; neural tube; and neuron neural crest derived. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1. Orthologous to human MYO5A (myosin VA). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See myo5aa in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (38899883..39043798)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (38918745..39061366)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene atos homolog A Neighboring gene cAMP-regulated phosphoprotein 19a Neighboring gene zgc:171509 Neighboring gene guanine nucleotide binding protein (G protein), beta 5b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish goosepimples/myosin Vb mutant exhibits cellular attributes of human microvillus inclusion disease. Sidhaye J, et al. Mech Dev, 2016 Nov. PMID 27497746, Free PMC Article
    2. Myosin Vb mediated plasma membrane homeostasis regulates peridermal cell size and maintains tissue homeostasis in the zebrafish epidermis. Sonal, et al. PLoS Genet, 2014 Sep. PMID 25233349, Free PMC Article
    3. Effects of penthiopyrad on the development and behaviour of zebrafish in early-life stages. Qian L, et al. Chemosphere, 2019 Jan. PMID 30265925
    4. Expression of unconventional myosin genes during neuronal development in zebrafish. Sittaramane V, et al. Gene Expr Patterns, 2008 Feb. PMID 18078791, Free PMC Article
    5. Mechanisms of developmental toxicity in zebrafish embryos (Danio rerio) induced by boscalid. Qian L, et al. Sci Total Environ, 2018 Sep 1. PMID 29631138

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle transport along actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myosin-Va; unconventional myosin-Va
    Names
    heavy polypeptide 12
    myosin VA (heavy polypeptide 12, myoxin)
    myoxin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      38899883..39043798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009293796.3 → XP_009292071.1  unconventional myosin-Va isoform X3

      UniProtKB/TrEMBL
      A0A8M3AV30
      Conserved Domains (4) summary
      smart00015
      Location:788 → 810
      IQ; Calmodulin-binding motif
      cd15478
      Location:1474 → 1848
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:83 → 751
      MYSc_Myo5; class V myosin, motor domain
      cl25732
      Location:919 → 1278
      SMC_N; RecF/RecN/SMC N terminal domain

    2. XM_021467867.1 → XP_021323542.1  unconventional myosin-Va isoform X9

      UniProtKB/TrEMBL
      A0A8M9P1G5
      Conserved Domains (4) summary
      smart00015
      Location:788 → 810
      IQ; Calmodulin-binding motif
      cd01380
      Location:83 → 751
      MYSc_Myo5; class V myosin, motor domain
      pfam02736
      Location:12 → 51
      Myosin_N; Myosin N-terminal SH3-like domain
      cl25732
      Location:919 → 1278
      SMC_N; RecF/RecN/SMC N terminal domain

    3. XM_021467868.1 → XP_021323543.1  unconventional myosin-Va isoform X10

      UniProtKB/TrEMBL
      A0A8M9PAJ4
      Conserved Domains (4) summary
      smart00015
      Location:790 → 812
      IQ; Calmodulin-binding motif
      cd01380
      Location:85 → 753
      MYSc_Myo5; class V myosin, motor domain
      pfam02736
      Location:14 → 53
      Myosin_N; Myosin N-terminal SH3-like domain
      cl25732
      Location:921 → 1280
      SMC_N; RecF/RecN/SMC N terminal domain

    4. XM_009293797.3 → XP_009292072.1  unconventional myosin-Va isoform X4

      UniProtKB/TrEMBL
      A0A8M3AS48
      Conserved Domains (5) summary
      smart00015
      Location:790 → 812
      IQ; Calmodulin-binding motif
      cd15478
      Location:1473 → 1847
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:85 → 753
      MYSc_Myo5; class V myosin, motor domain
      pfam09787
      Location:1209 → 1382
      Golgin_A5; Golgin subfamily A member 5
      cl25732
      Location:921 → 1280
      SMC_N; RecF/RecN/SMC N terminal domain

    5. XM_009293798.3 → XP_009292073.1  unconventional myosin-Va isoform X5

      UniProtKB/TrEMBL
      A0A8M3AJS5
      Related
      ENSDARP00000139407.2, ENSDART00000159834.2
      Conserved Domains (5) summary
      smart00015
      Location:789 → 811
      IQ; Calmodulin-binding motif
      cd15478
      Location:1472 → 1846
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:85 → 752
      MYSc_Myo5; class V myosin, motor domain
      pfam09787
      Location:1208 → 1381
      Golgin_A5; Golgin subfamily A member 5
      cl25732
      Location:920 → 1279
      SMC_N; RecF/RecN/SMC N terminal domain

    6. XM_009293794.3 → XP_009292069.1  unconventional myosin-Va isoform X1

      UniProtKB/TrEMBL
      A0A8M9PPP8
      Conserved Domains (4) summary
      smart00015
      Location:790 → 812
      IQ; Calmodulin-binding motif
      cd15478
      Location:1476 → 1850
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:85 → 753
      MYSc_Myo5; class V myosin, motor domain
      cl25732
      Location:921 → 1280
      SMC_N; RecF/RecN/SMC N terminal domain

    7. XM_017352118.2 → XP_017207607.1  unconventional myosin-Va isoform X11

      UniProtKB/TrEMBL
      A0A8M9PPQ8
      Conserved Domains (4) summary
      smart00015
      Location:789 → 811
      IQ; Calmodulin-binding motif
      cd15478
      Location:1480 → 1854
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:85 → 752
      MYSc_Myo5; class V myosin, motor domain
      cl25732
      Location:920 → 1279
      SMC_N; RecF/RecN/SMC N terminal domain

    8. XM_009293795.3 → XP_009292070.1  unconventional myosin-Va isoform X2

      UniProtKB/TrEMBL
      A0A8M9PW04
      Conserved Domains (4) summary
      smart00015
      Location:789 → 811
      IQ; Calmodulin-binding motif
      cd15478
      Location:1475 → 1849
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:85 → 752
      MYSc_Myo5; class V myosin, motor domain
      cl25732
      Location:920 → 1279
      SMC_N; RecF/RecN/SMC N terminal domain

    9. XM_005173675.4 → XP_005173732.1  unconventional myosin-Va isoform X6

      UniProtKB/TrEMBL
      A0A8M2BKY7
      Conserved Domains (4) summary
      smart00015
      Location:790 → 812
      IQ; Calmodulin-binding motif
      cd15478
      Location:1454 → 1828
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:85 → 753
      MYSc_Myo5; class V myosin, motor domain
      cl25732
      Location:899 → 1477
      SMC_N; RecF/RecN/SMC N terminal domain

    10. XM_009293800.3 → XP_009292075.1  unconventional myosin-Va isoform X8

      UniProtKB/TrEMBL
      A0A8M3B332
      Conserved Domains (4) summary
      smart00015
      Location:790 → 812
      IQ; Calmodulin-binding motif
      cd15478
      Location:1451 → 1825
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:85 → 753
      MYSc_Myo5; class V myosin, motor domain
      cl25732
      Location:899 → 1474
      SMC_N; RecF/RecN/SMC N terminal domain

    11. XM_005173676.4 → XP_005173733.1  unconventional myosin-Va isoform X7

      UniProtKB/TrEMBL
      A0A8M2BKY1
      Conserved Domains (4) summary
      smart00015
      Location:789 → 811
      IQ; Calmodulin-binding motif
      cd15478
      Location:1453 → 1827
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:85 → 752
      MYSc_Myo5; class V myosin, motor domain
      cl25732
      Location:898 → 1476
      SMC_N; RecF/RecN/SMC N terminal domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395043.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      104577..256242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473336.1 → XP_021329011.1  unconventional myosin-Va isoform X9

      UniProtKB/TrEMBL
      A0A8M9P1G5
      Conserved Domains (4) summary
      smart00015
      Location:788 → 810
      IQ; Calmodulin-binding motif
      cd01380
      Location:83 → 751
      MYSc_Myo5; class V myosin, motor domain
      pfam02736
      Location:12 → 51
      Myosin_N; Myosin N-terminal SH3-like domain
      cl25732
      Location:919 → 1278
      SMC_N; RecF/RecN/SMC N terminal domain

    2. XM_021473330.1 → XP_021329005.1  unconventional myosin-Va isoform X3

      UniProtKB/TrEMBL
      A0A8M3AV30
      Conserved Domains (4) summary
      smart00015
      Location:788 → 810
      IQ; Calmodulin-binding motif
      cd15478
      Location:1474 → 1848
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:83 → 751
      MYSc_Myo5; class V myosin, motor domain
      cl25732
      Location:919 → 1278
      SMC_N; RecF/RecN/SMC N terminal domain

    3. XM_021473337.1 → XP_021329012.1  unconventional myosin-Va isoform X10

      UniProtKB/TrEMBL
      A0A8M9PAJ4
      Conserved Domains (4) summary
      smart00015
      Location:790 → 812
      IQ; Calmodulin-binding motif
      cd01380
      Location:85 → 753
      MYSc_Myo5; class V myosin, motor domain
      pfam02736
      Location:14 → 53
      Myosin_N; Myosin N-terminal SH3-like domain
      cl25732
      Location:921 → 1280
      SMC_N; RecF/RecN/SMC N terminal domain

    4. XM_021473328.1 → XP_021329003.1  unconventional myosin-Va isoform X1

      UniProtKB/TrEMBL
      A0A8M9PPP8
      Conserved Domains (4) summary
      smart00015
      Location:790 → 812
      IQ; Calmodulin-binding motif
      cd15478
      Location:1476 → 1850
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:85 → 753
      MYSc_Myo5; class V myosin, motor domain
      cl25732
      Location:921 → 1280
      SMC_N; RecF/RecN/SMC N terminal domain

    5. XM_021473333.1 → XP_021329008.1  unconventional myosin-Va isoform X6

      UniProtKB/TrEMBL
      A0A8M2BKY7
      Conserved Domains (4) summary
      smart00015
      Location:790 → 812
      IQ; Calmodulin-binding motif
      cd15478
      Location:1454 → 1828
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:85 → 753
      MYSc_Myo5; class V myosin, motor domain
      cl25732
      Location:899 → 1477
      SMC_N; RecF/RecN/SMC N terminal domain

    6. XM_021473335.1 → XP_021329010.1  unconventional myosin-Va isoform X8

      UniProtKB/TrEMBL
      A0A8M3B332
      Conserved Domains (4) summary
      smart00015
      Location:790 → 812
      IQ; Calmodulin-binding motif
      cd15478
      Location:1451 → 1825
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:85 → 753
      MYSc_Myo5; class V myosin, motor domain
      cl25732
      Location:899 → 1474
      SMC_N; RecF/RecN/SMC N terminal domain

    7. XM_021473338.1 → XP_021329013.1  unconventional myosin-Va isoform X11

      UniProtKB/TrEMBL
      A0A8M9PPQ8
      Conserved Domains (4) summary
      smart00015
      Location:789 → 811
      IQ; Calmodulin-binding motif
      cd15478
      Location:1480 → 1854
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:85 → 752
      MYSc_Myo5; class V myosin, motor domain
      cl25732
      Location:920 → 1279
      SMC_N; RecF/RecN/SMC N terminal domain

    8. XM_021473334.1 → XP_021329009.1  unconventional myosin-Va isoform X7

      UniProtKB/TrEMBL
      A0A8M2BKY1
      Conserved Domains (4) summary
      smart00015
      Location:789 → 811
      IQ; Calmodulin-binding motif
      cd15478
      Location:1453 → 1827
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:85 → 752
      MYSc_Myo5; class V myosin, motor domain
      cl25732
      Location:898 → 1476
      SMC_N; RecF/RecN/SMC N terminal domain

    9. XM_021473331.1 → XP_021329006.1  unconventional myosin-Va isoform X4

      UniProtKB/TrEMBL
      A0A8M3AS48
      Conserved Domains (5) summary
      smart00015
      Location:790 → 812
      IQ; Calmodulin-binding motif
      cd15478
      Location:1473 → 1847
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:85 → 753
      MYSc_Myo5; class V myosin, motor domain
      pfam09787
      Location:1209 → 1382
      Golgin_A5; Golgin subfamily A member 5
      cl25732
      Location:921 → 1280
      SMC_N; RecF/RecN/SMC N terminal domain

    10. XM_021473329.1 → XP_021329004.1  unconventional myosin-Va isoform X2

      UniProtKB/TrEMBL
      A0A8M9PW04
      Conserved Domains (4) summary
      smart00015
      Location:789 → 811
      IQ; Calmodulin-binding motif
      cd15478
      Location:1475 → 1849
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:85 → 752
      MYSc_Myo5; class V myosin, motor domain
      cl25732
      Location:920 → 1279
      SMC_N; RecF/RecN/SMC N terminal domain

    11. XM_021473332.1 → XP_021329007.1  unconventional myosin-Va isoform X5

      UniProtKB/TrEMBL
      A0A8M3AJS5
      Conserved Domains (5) summary
      smart00015
      Location:789 → 811
      IQ; Calmodulin-binding motif
      cd15478
      Location:1472 → 1846
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:85 → 752
      MYSc_Myo5; class V myosin, motor domain
      pfam09787
      Location:1208 → 1381
      Golgin_A5; Golgin subfamily A member 5
      cl25732
      Location:920 → 1279
      SMC_N; RecF/RecN/SMC N terminal domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001080959.2: Suppressed sequence

      Description
      NM_001080959.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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