frem2a FRAS1 related extracellular matrix 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: frem2aprovided by ZNC
Official Full Name: FRAS1 related extracellular matrix 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-081119-3
See related: Ensembl:ENSDARG00000076856 AllianceGenome:ZFIN:ZDB-GENE-081119-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: bla
Summary: Acts upstream of or within fin morphogenesis. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in fin; fin fold pectoral fin bud; median fin fold; pharyngeal arch; and trunk. Human ortholog(s) of this gene implicated in Fraser syndrome 2 and isolated cryptophthalmia. Orthologous to human FREM2 (FRAS1 related extracellular matrix 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (25982247..26113240)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (26020648..26150554)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The fish gene complement includes fras1, frem1a, frem1b, frem2a, frem2b, and frem3, which display complex overlapping and complementary expression patterns in developing tissues including the pharyngeal arches, hypochord, musculature, and otic vesicle.
Title: Expression of the fras1/frem gene family during zebrafish development and fin morphogenesis.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell communication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: FRAS1-related extracellular matrix protein 2; FRAS1-related extracellular matrix protein 2a

Names: Fras-related extracellular matrix protein 2a; Fras1 related extracellular matrix protein 2a; blasen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001137657.1 → NP_001131129.1 FRAS1-related extracellular matrix protein 2a precursor

See identical proteins and their annotated locations for NP_001131129.1

Status: PROVISIONAL

Source sequence(s)

BK006471

UniProtKB/TrEMBL

B6IDE6

Conserved Domains (3) summary

pfam03160
Location:1951 → 2046

Calx-beta; Calx-beta domain

pfam16184
Location:1424 → 1565

Cadherin_3; Cadherin-like

cl02522
Location:1715 → 1802

Calx-beta; Calx-beta domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

25982247..26113240

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005155380.4 → XP_005155437.1 FRAS1-related extracellular matrix protein 2 isoform X1

See identical proteins and their annotated locations for XP_005155437.1

UniProtKB/TrEMBL

A0A8M2B2A0, D7PS91

Related

ENSDARP00000102786.3, ENSDART00000108808.5

Conserved Domains (3) summary

pfam03160
Location:1951 → 2046

Calx-beta; Calx-beta domain

pfam16184
Location:1424 → 1565

Cadherin_3; Cadherin-like

cl02522
Location:1715 → 1802

Calx-beta; Calx-beta domain