gfi1aa growth factor independent 1A transcription repressor a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gfi1aaprovided by ZNC
Official Full Name: growth factor independent 1A transcription repressor aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-534
See related: Ensembl:ENSDARG00000020746 AllianceGenome:ZFIN:ZDB-GENE-050522-534
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gfi1a; gfi1.1; zgc:113277
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within primitive erythrocyte differentiation. Predicted to be active in nucleoplasm. Is expressed in several structures, including artery; hematopoietic cell; intermediate cell mass of mesoderm; mesoderm; and sensory system. Human ortholog(s) of this gene implicated in acute myeloid leukemia and severe congenital neutropenia 2. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (10766744..10785640)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (10983145..11002041)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Znf687 recruits Brd4-Smrt complex to regulate gfi1aa during neutrophil development.
Title: Znf687 recruits Brd4-Smrt complex to regulate gfi1aa during neutrophil development.
Irf2bp2a regulates terminal granulopoiesis through proteasomal degradation of Gfi1aa in zebrafish.
Title: Irf2bp2a regulates terminal granulopoiesis through proteasomal degradation of Gfi1aa in zebrafish.
Genetic and epigenetic orchestration of Gfi1aa-Lsd1-cebpa in zebrafish neutrophil development.
Title: Genetic and epigenetic orchestration of Gfi1aa-Lsd1-cebpa in zebrafish neutrophil development.
gfi1aa and gfi1b are expressed in the primitive and definitive sites of hematopoiesis in zebrafish.
Title: Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis.
This publication demonstrates the role of gfi1aa in regulation of primitive hematopoietic progenitors.
Title: Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemangioblast cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within primitive erythrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within primitive erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within primitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: growth factor independent 1A transcription repressor a

Names: growth factor independent 1.1; growth factor independent 1aa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020776.1 → NP_001018612.1 growth factor independent 1A transcription repressor a

See identical proteins and their annotated locations for NP_001018612.1

Status: PROVISIONAL

Source sequence(s)

BC095882

UniProtKB/TrEMBL

Q501T1

Related

ENSDARP00000017502.8, ENSDART00000015379.9

Conserved Domains (2) summary

sd00017
Location:277 → 297

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:317 → 342

zf-H2C2_2; Zinc-finger double domain