crmp1 collapsin response mediator protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: crmp1provided by ZNC
Official Full Name: collapsin response mediator protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050720-1
See related: Ensembl:ENSDARG00000056742 AllianceGenome:ZFIN:ZDB-GENE-050720-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: CRMP-1
Summary: Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds. Predicted to act upstream of or within axon guidance and microtubule cytoskeleton organization. Predicted to be located in cytoplasm. Is expressed in brain and retina. Orthologous to human CRMP1 (collapsin response mediator protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (14343317..14364712)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (13656643..13678214)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crmp1 is expressed in numerous sites in the developing nervous system
Title: Live imaging of endogenous Collapsin response mediator protein-1 expression at subcellular resolution during zebrafish nervous system development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
NOT enables dihydropyrimidinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
NOT involved_in pyrimidine nucleobase catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dihydropyrimidinase-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020725.1 → NP_001018561.1 dihydropyrimidinase-related protein 1

See identical proteins and their annotated locations for NP_001018561.1

Status: PROVISIONAL

Source sequence(s)

AY987372

UniProtKB/TrEMBL

Q52PJ6

Related

ENSDARP00000064467.5, ENSDART00000064468.7

Conserved Domains (2) summary

PRK09060
Location:20 → 470

PRK09060; dihydroorotase; Validated

cd01314
Location:20 → 469

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

14343317..14364712

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005159843.4 → XP_005159900.1 dihydropyrimidinase-related protein 1 isoform X1

UniProtKB/TrEMBL

A0A8M2B701

Conserved Domains (2) summary

PRK09060
Location:119 → 569

PRK09060; dihydroorotase; Validated

cd01314
Location:119 → 568

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...