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    ALAS1 5'-aminolevulinate synthase 1 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 460416, updated on 6-Jun-2024

    Summary

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    Official Symbol
    ALAS1provided by VGNC
    Official Full Name
    5'-aminolevulinate synthase 1provided by VGNC
    Primary source
    VGNC:VGNC:1728
    Locus tag
    CK820_G0004995
    See related
    Ensembl:ENSPTRG00000014991
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See ALAS1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 2 NC_086015.1 (56243234..56259465)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 3 NC_072401.1 (56242908..56259136)

    Chromosome 2 - NC_086015.1Genomic Context describing neighboring genes Neighboring gene POC1 centriolar protein A Neighboring gene fructose-bisphosphate aldolase A-like Neighboring gene twinfilin actin binding protein 2 Neighboring gene uncharacterized LOC134809446 Neighboring gene twinfilin actin binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 5-aminolevulinate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in erythrocyte development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hemoglobin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    5-aminolevulinate synthase, nonspecific, mitochondrial; 5-aminolevulinate synthase, non-specific, mitochondrial
    Names
    aminolevulinate, delta, synthase 1
    aminolevulinate, delta-, synthase 1
    XP_009443860.1
    XP_054537902.1
    XP_054537903.1
    XP_063662881.1
    XP_516501.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_086015.1 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      56243234..56259465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_516501.7 → XP_516501.2  5-aminolevulinate synthase, non-specific, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_516501.2

      UniProtKB/TrEMBL
      A0A2J8P8J0, A0A6D2VSE5, H2QMR0, K7DQ03
      Related
      ENSPTRP00000025879.4
      Conserved Domains (2) summary
      pfam09029
      Location:2 → 137
      Preseq_ALAS; 5-aminolevulinate synthase presequence
      cl18945
      Location:197 → 602
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    2. XM_009445585.2 → XP_009443860.1  5-aminolevulinate synthase, non-specific, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_009443860.1

      UniProtKB/TrEMBL
      A0A2J8P8J0, A0A6D2VSE5, H2QMR0, K7DQ03
      Conserved Domains (2) summary
      pfam09029
      Location:2 → 137
      Preseq_ALAS; 5-aminolevulinate synthase presequence
      cl18945
      Location:197 → 602
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    3. XM_054681928.2 → XP_054537903.1  5-aminolevulinate synthase, non-specific, mitochondrial isoform X2

      UniProtKB/TrEMBL
      K7DQ03

    4. XM_063806811.1 → XP_063662881.1  5-aminolevulinate synthase, non-specific, mitochondrial isoform X2

      UniProtKB/TrEMBL
      K7DQ03

    5. XM_054681927.2 → XP_054537902.1  5-aminolevulinate synthase, non-specific, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A2J8P8J0, A0A6D2VSE5, H2QMR0, K7DQ03

    RNA

    1. XR_010155599.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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