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    stx2a syntaxin 2a [ Danio rerio (zebrafish) ]

    Gene ID: 445167, updated on 25-Apr-2024

    Summary

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    Official Symbol
    stx2aprovided by ZNC
    Official Full Name
    syntaxin 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040801-80
    See related
    Ensembl:ENSDARG00000004618 AllianceGenome:ZFIN:ZDB-GENE-040801-80
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fk28f06; wu:fk28f06; zgc:101111
    Summary
    Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport; synaptic vesicle fusion to presynaptic active zone membrane; and vesicle docking. Predicted to act upstream of or within acrosome reaction; cell differentiation; and vesicle-mediated transport. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in presynaptic active zone membrane and synaptic vesicle. Predicted to be integral component of membrane. Orthologous to human STX2 (syntaxin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See stx2a in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (17950403..17956734, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (17914648..17920098, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene stomatin Neighboring gene gelsolin a Neighboring gene retinoid X receptor, alpha a Neighboring gene uncharacterized LOC110438227 Neighboring gene dynein, axonemal, intermediate chain 1, paralog 2 Neighboring gene vav 2 guanine nucleotide exchange factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    syntaxin 2a; uncharacterized protein LOC445167

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003561.1 → NP_001003561.1  syntaxin 2a

      See identical proteins and their annotated locations for NP_001003561.1

      Status: PROVISIONAL

      Source sequence(s)
      BC077121
      UniProtKB/TrEMBL
      Q6DEJ2
      Related
      ENSDARP00000005867.8, ENSDART00000026737.10
      Conserved Domains (3) summary
      cd15848
      Location:125 → 187
      SNARE_syntaxin1-like; SNARE motif of syntaxin 1 and related proteins
      pfam00804
      Location:25 → 161
      Syntaxin; Syntaxin
      cl00143
      Location:25 → 89
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      17950403..17956734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161168.4 → XP_005161225.1  uncharacterized protein LOC445167 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B849, E9QCC0
      Related
      ENSDARP00000123358.1, ENSDART00000148154.2
      Conserved Domains (3) summary
      cd00179
      Location:25 → 178
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
      cd15848
      Location:188 → 250
      SNARE_syntaxin1-like; SNARE motif of syntaxin 1 and related proteins
      pfam00804
      Location:25 → 224
      Syntaxin; Syntaxin
    Nucleotide Protein Strain
    Heading Accession and Version

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