ncf1 neutrophil cytosolic factor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ncf1provided by ZNC
Official Full Name: neutrophil cytosolic factor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-031006-6
See related: Ensembl:ENSDARG00000033735 AllianceGenome:ZFIN:ZDB-GENE-031006-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb893
Summary: Predicted to enable superoxide-generating NADPH oxidase activator activity. Acts upstream of or within defense response to fungus and respiratory burst. Predicted to be part of NADPH oxidase complex. Predicted to be active in cytoplasm. Is expressed in cardiovascular system; extension; macrophage; and myeloid leukocyte. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome; autosomal recessive chronic granulomatous disease cytochrome b-positive type I; and chronic granulomatous disease. Orthologous to human NCF1 (neutrophil cytosolic factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (61432541..61445697, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (60747820..60760976, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables superoxide-generating NADPH oxidase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide-generating NADPH oxidase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in respiratory burst	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within respiratory burst	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in superoxide anion generation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of NADPH oxidase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neutrophil cytosol factor 1

Names: p47phox

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030071.2 → NP_001025242.1 neutrophil cytosol factor 1

See identical proteins and their annotated locations for NP_001025242.1

Status: PROVISIONAL

Source sequence(s)

AY972158

UniProtKB/TrEMBL

Q4Z8P3

Related

ENSDARP00000050897.4, ENSDART00000050898.5

Conserved Domains (5) summary

cd06887
Location:6 → 123

PX_p47phox; The phosphoinositide binding Phox Homology domain of the p47phox subunit of NADPH oxidase

cd12021
Location:162 → 214

SH3_p47phox_1; First or N-terminal Src homology 3 domain of the p47phox subunit of NADPH oxidase, also called Neutrophil Cytosolic Factor 1

cd12022
Location:232 → 284

SH3_p47phox_2; Second or C-terminal Src homology 3 domain of the p47phox subunit of NADPH oxidase, also called Neutrophil Cytosolic Factor 1

pfam08944
Location:354 → 407

p47_phox_C; NADPH oxidase subunit p47Phox, C terminal domain

pfam16621
Location:286 → 335

NECFESHC; SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1