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    sPLA2 secretory Phospholipase A2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35665, updated on 10-May-2024

    Summary

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    Official Symbol
    sPLA2provided by FlyBase
    Official Full Name
    secretory Phospholipase A2provided by FlyBase
    Primary source
    FLYBASE:FBgn0033170
    Locus tag
    Dmel_CG11124
    See related
    AllianceGenome:FB:FBgn0033170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11124; CG14507; Dmel\CG11124; secretory phospholipase A[[2]]; sPLA[[2]]
    Summary
    Enables calcium-dependent phospholipase A2 activity. Predicted to be involved in arachidonic acid secretion and phospholipid metabolic process. Is expressed in organism. Orthologous to human PLA2G3 (phospholipase A2 group III). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See sPLA2 in Genome Data Viewer
    Location:
    43C1-43C1; 2-56 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7442864..7443827)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3330369..3331332)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene sine oculis Neighboring gene long non-coding RNA:CR44203 Neighboring gene long non-coding RNA:CR44204 Neighboring gene uncharacterized protein Neighboring gene kappaB-Ras Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fatty acid 2-hydroxylase Neighboring gene long non-coding RNA:CR45320

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a gene encoding the Drosophila melanogaster phospholipase A2. Ryu Y, et al. Biochim Biophys Acta, 2003 Aug 25. PMID 12932833
    2. Disruption of INOS, a Gene Encoding myo-Inositol Phosphate Synthase, Causes Male Sterility in Drosophila melanogaster. Jackson NAM, et al. G3 (Bethesda), 2018 Aug 30. PMID 29991509, Free PMC Article
    3. Gene induction following wounding of wild-type versus macrophage-deficient Drosophila embryos. Stramer B, et al. EMBO Rep, 2008 May. PMID 18344972, Free PMC Article
    4. Drosophila Fed ARA and EPA Yields Eicosanoids, 15S-Hydroxy-5Z,8Z, 11Z, 13E-Eicosatetraenoic Acid, and 15S-Hydroxy-5Z,8Z,11Z,13E,17Z-Eicosapentaenoic Acid. Tan L, et al. Lipids, 2016 Apr. PMID 26931457
    5. Drosophila spermatid individualization is sensitive to temperature and fatty acid metabolism. Ben-David G, et al. Spermatogenesis, 2015 Jan-Apr. PMID 26413411, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium-dependent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonic acid secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    secretory phospholipase A2
    Names
    CG11124-PA
    CG11124-PB
    CG11124-PC
    sPLA2-PA
    sPLA2-PB
    sPLA2-PC
    secreted phospholipase A2
    NP_001014501.1
    NP_610277.1
    NP_724556.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7442864..7443827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014501.3 → NP_001014501.1  secretory phospholipase A2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014501.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWR6, Q6XPX3
      Conserved Domains (1) summary
      cd04704
      Location:43 → 139
      PLA2_bee_venom_like; PLA2_bee_venom_like: A sub-family of Phospholipase A2, similar to bee venom PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the ...

    2. NM_136433.3 → NP_610277.1  secretory phospholipase A2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610277.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZB2
      Related
      FBpp0099485
      Conserved Domains (1) summary
      cl05417
      Location:43 → 101
      PLA2_like; PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    3. NM_165523.3 → NP_724556.1  secretory phospholipase A2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724556.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWR6, Q6XPX3
      Related
      FBpp0099484
      Conserved Domains (1) summary
      cd04704
      Location:43 → 139
      PLA2_bee_venom_like; PLA2_bee_venom_like: A sub-family of Phospholipase A2, similar to bee venom PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AWR6 Q6AWR6
    Q6XPX3 Q6XPX3
    Q8SZB2 Q8SZB2

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