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    STAT5A signal transducer and activator of transcription 5A [ Bos taurus (cattle) ]

    Gene ID: 282375, updated on 11-Apr-2024

    Summary

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    Official Symbol
    STAT5Aprovided by VGNC
    Official Full Name
    signal transducer and activator of transcription 5Aprovided by VGNC
    Primary source
    VGNC:VGNC:35372
    See related
    BGD:BT22222; Ensembl:ENSBTAG00000009496
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    STATA5; STAT5A/MGF
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    Genomic context

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    See STAT5A in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (42395459..42415495)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene signal transducer and activator of transcription 5B Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene signal transducer and activator of transcription 3 Neighboring gene caveolae associated protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Association of STAT5A Gene Variants with Milk Production Traits in Agerolese Cattle. Selvaggi M, et al. Biochem Genet, 2017 Apr. PMID 27885437
    2. Expression pattern of STAT5A gene during early bovine embryogenesis. Flisikowski K, et al. Zygote, 2015 Apr. PMID 23981721
    3. Stat5a increases lactation of dairy cow mammary gland epithelial cells cultured in vitro. Liu XF, et al. In Vitro Cell Dev Biol Anim, 2012 Oct. PMID 23054437
    4. Study on the STAT5A/AvaI polymorphism in Jersey cows and association with milk production traits. Dario C, et al. Mol Biol Rep, 2011 Nov. PMID 21390501
    5. Genetic polymorphism of STAT5A protein: relationships with production traits and milk composition in Italian Brown cattle. Selvaggi M, et al. J Dairy Res, 2009 Nov. PMID 19638264

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Impact of STAT5A-CNVs on growth traits in Chinese beef cattle breeds.
      Title: Impact of STAT5A-CNVs on growth traits in Chinese beef cattle breeds.
    2. This study showed that the IGF-1 SnaBI TT appears to be associated with fewer days to ovulation and lesser calving to conseption interval of lactating dairy cows and had an additive association with the GHR AluI T allele on indicators for improvement of fertility.
      Title: Association of polymorphisms in the IGF-I, GHR and STAT5A genes with serum IGF-I concentration and reproductive performance of Holstein dairy cows.
    3. Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 and mTOR signaling pathways.
      Title: Methionyl-Methionine Promotes α-s1 Casein Synthesis in Bovine Mammary Gland Explants by Enhancing Intracellular Substrate Availability and Activating JAK2-STAT5 and mTOR-Mediated Signaling Pathways.
    4. There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.
      Title: Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows.
    5. Milk production traits were analyzed for each animal in the first, second, third, and fourth lactation. No genetic variability was found at STAT5A/AvaI locus. At STAT5A/MslI locus, the frequencies of T and C alleles were 0.875 and 0.125, respectively. Significant differences between genotypes were found
      Title: Association of STAT5A Gene Variants with Milk Production Traits in Agerolese Cattle.
    6. Results indicate that SNPs in STAT5A and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
      Title: Genetic effects of single nucleotide polymorphisms in JAK2 and STAT5A genes on susceptibility of Chinese Holsteins to mastitis.
    7. The embryonic STAT5A gene is primarily activated by maternal gene products and the most abundant STAT5A expression occurred at the 2-cell stage blastocysts.
      Title: Expression pattern of STAT5A gene during early bovine embryogenesis.
    8. INVESTIGATION OF STAT5A, FSHR AND LHR GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS
      Title: INVESTIGATION OF STAT5A, FSHR AND LHR GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS (EAST ANATOLLAN RED, SOUTH ANATOLIAN RED, TURKISH GREY, ANATOLIAN BLACK AND ZAVOT).
    9. The Stat5a gene is associated with an increase in lactation of mammary gland epithelial cells.
      Title: Stat5a increases lactation of dairy cow mammary gland epithelial cells cultured in vitro.
    10. STAT5A/AvaI polymorphism seems to be a promising indirect marker to improve milk production traits in cattle.
      Title: Study on the STAT5A/AvaI polymorphism in Jersey cows and association with milk production traits.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in growth hormone receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    signal transducer and activator of transcription 5A
    Names
    STAT5A, Mammary Gland Factor
    mammary gland factor
    signal transducer and activator of transcription factor 5A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012673.1 → NP_001012691.1  signal transducer and activator of transcription 5A

      See identical proteins and their annotated locations for NP_001012691.1

      Status: PROVISIONAL

      Source sequence(s)
      Z72482
      UniProtKB/TrEMBL
      F1MER9
      Related
      ENSBTAP00000067878.1, ENSBTAT00000073514.2
      Conserved Domains (4) summary
      cd10421
      Location:573 → 712
      SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins
      pfam01017
      Location:141 → 330
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:332 → 582
      STAT_bind; STAT protein, DNA binding domain
      pfam02865
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      42395459..42415495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059877731.1 → XP_059733714.1  signal transducer and activator of transcription 5A isoform X1

      Related
      ENSBTAP00000075609.1, ENSBTAT00000092983.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95115.2 GenPept UniProtKB/Swiss-Prot:Q95115

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.