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    mast3b microtubule associated serine/threonine kinase 3b [ Danio rerio (zebrafish) ]

    Gene ID: 100535762, updated on 25-Apr-2024

    Summary

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    Official Symbol
    mast3bprovided by ZNC
    Official Full Name
    microtubule associated serine/threonine kinase 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-111209-1
    See related
    Ensembl:ENSDARG00000086505 AllianceGenome:ZFIN:ZDB-GENE-111209-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and peptidyl-serine phosphorylation. Predicted to act upstream of or within protein phosphorylation. Orthologous to human MAST3 (microtubule associated serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See mast3b in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (13280713..13353106, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (13223200..13295530, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene ATP synthase F1 subunit beta Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 11b Neighboring gene interleukin 12 receptor subunit beta 1 Neighboring gene homer scaffold protein 3b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within midbrain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated serine/threonine-protein kinase 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      13280713..13353106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155958.4 → XP_005156015.1  microtubule-associated serine/threonine-protein kinase 3 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B2L6
      Conserved Domains (4) summary
      smart00220
      Location:390 → 663
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00228
      Location:935 → 1019
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:389 → 668
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:76 → 350
      DUF1908; Domain of unknown function (DUF1908)

    2. XM_009305917.3 → XP_009304192.1  microtubule-associated serine/threonine-protein kinase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8M3B6T6
      Conserved Domains (4) summary
      smart00220
      Location:396 → 669
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00228
      Location:941 → 1025
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:395 → 674
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:76 → 357
      DUF1908; Domain of unknown function (DUF1908)

    3. XM_009305916.3 → XP_009304191.1  microtubule-associated serine/threonine-protein kinase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AXH0
      Conserved Domains (4) summary
      smart00220
      Location:397 → 670
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00228
      Location:942 → 1026
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:396 → 675
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:76 → 357
      DUF1908; Domain of unknown function (DUF1908)

    4. XM_003199469.5 → XP_003199517.2  microtubule-associated serine/threonine-protein kinase 3 isoform X5

      UniProtKB/TrEMBL
      A0A8M1RIX4
      Related
      ENSDARP00000130092.1, ENSDART00000164978.2
      Conserved Domains (4) summary
      smart00220
      Location:375 → 648
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00228
      Location:920 → 1004
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:374 → 653
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:61 → 335
      DUF1908; Domain of unknown function (DUF1908)

    5. XM_009305918.3 → XP_009304193.1  microtubule-associated serine/threonine-protein kinase 3 isoform X4

      UniProtKB/TrEMBL
      A0A8M3B3Z1
      Conserved Domains (4) summary
      smart00220
      Location:382 → 655
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00228
      Location:927 → 1011
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd05609
      Location:381 → 660
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:61 → 342
      DUF1908; Domain of unknown function (DUF1908)
    Nucleotide Protein Strain
    Heading Accession and Version

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