dmgdh dimethylglycine dehydrogenase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dmgdhprovided by ZNC
Official Full Name: dimethylglycine dehydrogenaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080227-8
See related: AllianceGenome:ZFIN:ZDB-GENE-080227-8
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable dimethylglycine dehydrogenase activity. Predicted to be active in mitochondrial matrix. Orthologous to human DMGDH (dimethylglycine dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (51461..74823)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (105360..128729)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc16c06.x1 (e-PCR)
- UniSTS:192779

Z8230 (e-PCR)
- UniSTS:18229

Z8073 (e-PCR)
- UniSTS:78716

G47723 (e-PCR)
- UniSTS:108495

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables dimethylglycine dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dimethylglycine dehydrogenase, mitochondrial

XP_021324608.1

EC 1.5.8.4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

51461..74823

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021468933.1 → XP_021324608.1 dimethylglycine dehydrogenase, mitochondrial

UniProtKB/TrEMBL

A0A8M9PCV7

Conserved Domains (3) summary

COG0404
Location:466 → 855

GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]

COG0665
Location:44 → 433

DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

pfam16350
Location:419 → 466

FAO_M; FAD dependent oxidoreductase central domain