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    GAGE12G G antigen 12G [ Homo sapiens (human) ]

    Gene ID: 645073, updated on 10-Oct-2023

    Summary

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    Official Symbol
    GAGE12Gprovided by HGNC
    Official Full Name
    G antigen 12Gprovided by HGNC
    Primary source
    HGNC:HGNC:31907
    See related
    Ensembl:ENSG00000215269 MIM:300731; AllianceGenome:HGNC:31907
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AL4; CT4.7; GAGE-12G
    Expression
    Restricted expression toward testis (RPKM 163.8) See more
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    Genomic context

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    See GAGE12G in Genome Data Viewer
    Location:
    Xp11.23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (49570397..49577757)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (48886258..48893621)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (49335000..49342360)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene G antigen 12E Neighboring gene G antigen 12F Neighboring gene G antigen 12H Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:49354271-49354992 Neighboring gene G antigen 2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220. Hou P, et al. Cancer Res, 2017 Aug 15. PMID 28625976, Free PMC Article
    2. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    3. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC132611

    General protein information

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    Preferred Names
    G antigen 12G
    Names
    G antigen 12F/G/I
    G antigen 12I
    cancer/testis antigen 4.7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098409.4 → NP_001091879.1  G antigen 12G isoform 1

      See identical proteins and their annotated locations for NP_001091879.1

      Status: VALIDATED

      Source sequence(s)
      AC142497
      Consensus CDS
      CCDS43947.1
      UniProtKB/Swiss-Prot
      B7ZM13, O76087, P0CL80, P0CL81, P0CL82, Q4V324, Q66I50
      UniProtKB/TrEMBL
      B7ZVY3
      Related
      ENSP00000416249.1, ENST00000445148.2
      Conserved Domains (1) summary
      pfam05831
      Location:1 → 111
      GAGE; GAGE protein

    2. NM_001354422.1 → NP_001341351.1  G antigen 12G isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC142497
      Conserved Domains (1) summary
      pfam05831
      Location:1 → 69
      GAGE; GAGE protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      49570397..49577757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      48886258..48893621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CL81.1 GenPept UniProtKB/Swiss-Prot:P0CL81

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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