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    ELP4 Elongator subunit ELP4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856002, updated on 11-Apr-2024

    Summary

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    Gene symbol
    ELP4
    Gene description
    Elongator subunit ELP4
    Primary source
    SGD:S000006022
    Locus tag
    YPL101W
    See related
    AllianceGenome:SGD:S000006022
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HAP1; KTI9; TOT7
    Summary
    Contributes to ATP hydrolysis activity and tRNA binding activity. Involved in regulation of transcription by RNA polymerase II and tRNA wobble uridine modification. Located in cytoplasm. Part of elongator holoenzyme complex. Human ortholog(s) of this gene implicated in aniridia. Orthologous to human ELP4 (elongator acetyltransferase complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (360209..361579)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene aspartate--tRNA ligase MSD1 Neighboring gene N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D Neighboring gene Atg21p Neighboring gene Ina17p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [The Elp4 subunit of human Elongator complex partially complements the growth defects of yeast ELP4 deletion strain]. Li F, et al. Yi Chuan Xue Bao, 2004 Jul. PMID 15473317
    2. Novel domains and orthologues of eukaryotic transcription elongation factors. Ponting CP. Nucleic Acids Res, 2002 Sep 1. PMID 12202748, Free PMC Article
    3. Kluyveromyces lactis zymocin mode of action is linked to RNA polymerase II function via Elongator. Jablonowski D, et al. Mol Microbiol, 2001 Nov. PMID 11737649
    4. Physical and functional interaction between Elongator and the chromatin-associated Kti12 protein. Petrakis TG, et al. J Biol Chem, 2005 May 20. PMID 15772087
    5. Crystal structure of elongator subcomplex Elp4-6. Lin Z, et al. J Biol Chem, 2012 Jun 15. PMID 22556426, Free PMC Article

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of elongator holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Elongator subunit ELP4
    NP_015224.1
    • Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity; null mutation is functionally complemented by human ELP4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      360209..361579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183915.1 → NP_015224.1  TPA: Elongator subunit ELP4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015224.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3R5, Q02884
      UniProtKB/TrEMBL
      A0A8H4BW33, B3LKX1, B5VT61, C8ZIS9, N1NW31
      Conserved Domains (1) summary
      pfam05625
      Location:70 → 456
      PAXNEB; PAXNEB protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02884.1

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