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    YNL054W-B gag-pol fusion protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855672, updated on 13-Apr-2024

    Summary

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    Gene symbol
    YNL054W-B
    Gene description
    gag-pol fusion protein
    Primary source
    SGD:S000007385
    Locus tag
    YNL054W-B
    See related
    AllianceGenome:SGD:S000007385
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable several functions, including DNA polymerase activity; peptidase activity; and ribonuclease activity. Predicted to be involved in transposition, RNA-mediated. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (519456..524706)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene porin POR1 Neighboring gene tRNA-Asp Neighboring gene gag protein Neighboring gene Vac7p Neighboring gene tyrosine/serine/threonine protein phosphatase MSG5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A nucleocapsid functionality contained within the amino terminus of the Ty1 protease that is distinct and separable from proteolytic activity. Lawler JF Jr, et al. J Virol, 2002 Jan. PMID 11739699, Free PMC Article
    2. Kinetic pathway of pyrophosphorolysis by a retrotransposon reverse transcriptase. Pandey M, et al. PLoS One, 2008 Jan 2. PMID 18167548, Free PMC Article
    3. A Ty1 reverse transcriptase active-site aspartate mutation blocks transposition but not polymerization. Uzun O, et al. J Virol, 2001 Jul. PMID 11413300, Free PMC Article
    4. A Ty1 integrase nuclear localization signal required for retrotransposition. Moore SP, et al. Mol Cell Biol, 1998 Feb. PMID 9448008, Free PMC Article
    5. Invading the yeast nucleus: a nuclear localization signal at the C terminus of Ty1 integrase is required for transposition in vivo. Kenna MA, et al. Mol Cell Biol, 1998 Feb. PMID 9448009, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA nuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA-DNA hybrid ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-directed DNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA integration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA-templated DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrotransposition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in transposition IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in retrotransposon nucleocapsid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gag-pol fusion protein
    NP_001268465.1
    • TyB Gag-Pol protein; proteolytically processed to make the Gag, reverse transcriptase (RT), protease (PR), and integrase (IN) proteins that are required for retrotransposition

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      519456..524706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001281536.2 → NP_001268465.1  TPA: gag-pol fusion protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_001268465.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q99337, S6G3B3
      UniProtKB/TrEMBL
      C8Z7F1
      Conserved Domains (4) summary
      cd09272
      Location:1600 → 1736
      RNase_HI_RT_Ty1; Ty1/Copia family of RNase HI in long-term repeat retroelements
      pfam00665
      Location:664 → 782
      rve; Integrase core domain
      pfam01021
      Location:17 → 114
      TYA; TYA transposon protein
      pfam07727
      Location:1275 → 1468
      RVT_2; Reverse transcriptase (RNA-dependent DNA polymerase)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99337.1

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