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    BNI4 Bni4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855488, updated on 11-Apr-2024

    Summary

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    Gene symbol
    BNI4
    Gene description
    Bni4p
    Primary source
    SGD:S000005177
    Locus tag
    YNL233W
    See related
    AllianceGenome:SGD:S000005177
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable actin binding activity. Involved in chitin biosynthetic process and division septum assembly. Located in cellular bud neck septin collar and septin ring. Part of incipient cellular bud site. Human ortholog(s) of this gene implicated in Parkinson's disease; developmental and epileptic encephalopathy 70; and multiple sclerosis. Orthologous to several human genes including PHACTR1 (phosphatase and actin regulator 1); PHACTR2 (phosphatase and actin regulator 2); and PHACTR3 (phosphatase and actin regulator 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (211922..214600)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Sin4p Neighboring gene uncharacterized protein Neighboring gene exosome non-catalytic core subunit CSL4 Neighboring gene phosphatidylinositol transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Changes in Bni4 localization induced by cell stress in Saccharomyces cerevisiae. Larson JR, et al. J Cell Sci, 2010 Apr 1. PMID 20197406, Free PMC Article
    2. Saccharomyces cerevisiae Bni4p directs the formation of the chitin ring and also participates in the correct assembly of the septum structure. Sanz M, et al. Microbiology (Reading), 2004 Oct. PMID 15470103
    3. Protein phosphatase type 1 directs chitin synthesis at the bud neck in Saccharomyces cerevisiae. Larson JR, et al. Mol Biol Cell, 2008 Jul. PMID 18480405, Free PMC Article
    4. Chitin synthase III requires Chs4p-dependent translocation of Chs3p into the plasma membrane. Reyes A, et al. J Cell Sci, 2007 Jun 15. PMID 17519287
    5. A Bni4-Glc7 phosphatase complex that recruits chitin synthase to the site of bud emergence. Kozubowski L, et al. Mol Biol Cell, 2003 Jan. PMID 12529424, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results, together with a genetic correlation analysis, strongly support a functional model linking Slt2 MAP kinase and Pcl1, a Pho85 cyclin-dependent kinase, in septum assembly through Bni4.
      Title: Phosphorylation of Bni4 by MAP kinases contributes to septum assembly during yeast cytokinesis.
    2. Phosphorylation of Bni4 by Pcl-Pho85 is necessary for its localization to the bud neck, and the bud neck structure can be disrupted by overexpressing BNI4 in pcl1Deltapcl2Delta mutant cells.
      Title: Regulation of cell polarity through phosphorylation of Bni4 by Pho85 G1 cyclin-dependent kinases in Saccharomyces cerevisiae.
    3. the essential role of Bni4 is to target Glc7 to the neck and activate it toward substrates necessary for CSIII recruitment and synthesis of chitin at the bud neck
      Title: Protein phosphatase type 1 directs chitin synthesis at the bud neck in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in division septum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck septin collar IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in septin ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Bni4p
    NP_014166.1
    • Targeting subunit for Glc7p protein phosphatase; localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p; phosphorylation by Slt2p and Kss1p involved in regulating Bni4p in septum assembly

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      211922..214600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183071.1 → NP_014166.1  TPA: Bni4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014166.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0V9, P53858
      UniProtKB/TrEMBL
      A0A8H4FAN8, A6ZRK9, C7GPC6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53858.1

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