PRE5 proteasome core particle subunit alpha 6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855362, updated on 5-May-2024

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Summary

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Gene symbol: PRE5
Gene description: proteasome core particle subunit alpha 6
Primary source: SGD:S000004931
Locus tag: YMR314W
See related: AllianceGenome:SGD:S000004931
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in proteasome storage granule. Part of proteasome core complex, alpha-subunit complex. Used to study cancer. Orthologous to human PSMA1 (proteasome 20S subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (901709..902413)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that the dynamic gate can be opened by allosteric coupling to a tetrahedral transition state at any of the working active centers of proteasome.
Title: A tetrahedral transition state at the active sites of the 20S proteasome is coupled to opening of the alpha-ring channel.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in proteasomal ubiquitin-independent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasomal ubiquitin-independent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, alpha-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, alpha-subunit complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex, alpha-subunit complex	IEA Inferred from Electronic Annotation more info
located_in proteasome storage granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proteasome core particle subunit alpha 6

NP_014045.1

Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

901709..902413

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182825.1 → NP_014045.1 TPA: proteasome core particle subunit alpha 6 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014045.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0E1, P40302

UniProtKB/TrEMBL

A0A6A5PTH4, A6ZN31, B3LMK2, B5VQ80, C7GPU9, C8ZFI5, G2WL23, N1P645

Conserved Domains (1) summary

cl00467
Location:6 → 217

Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
3JCO_F.1
3JCO_f.1
3JCP_F.1
3JCP_f.1
3UN4_E.1
3UN4_S.1
3UN8_E.1
3UN8_S.1
3WXR_F.1
3WXR_T.1
4JSQ_E.1
4JSQ_S.1
4JSU_E.1
4JSU_S.1
4JT0_E.1
4JT0_S.1
4LTC_E.1
4LTC_S.1
4NNN_E.1
4NNN_S.1
4NNW_E.1
4NNW_S.1
4NO1_E.1
4NO1_S.1
4NO6_E.1
4NO6_S.1
4NO8_E.1
4NO8_S.1
4NO9_E.1
4NO9_S.1
4Q1S_E.1
4Q1S_S.1
4QBY_E.1
4QBY_S.1
4QLQ_E.1
4QLQ_S.1
4QLS_E.1
4QLS_S.1
4QLT_E.1
4QLT_S.1
4QLU_E.1
4QLU_S.1
4QLV_E.1
4QLV_S.1
4QUX_E.1
4QUX_S.1
4QUY_E.1
4QUY_S.1
4QV0_E.1
4QV0_S.1
4QV1_E.1
4QV1_S.1
4QV3_E.1
4QV3_S.1
4QV4_E.1
4QV4_S.1
4QV5_E.1
4QV5_S.1
4QV6_E.1
4QV6_S.1
4QV7_E.1
4QV7_S.1
4QV8_E.1
4QV8_S.1
4QV9_E.1
4QV9_S.1
4QVL_E.1
4QVL_S.1
4QVM_E.1
4QVM_S.1
4QVN_E.1
4QVN_S.1
4QVP_E.1
4QVP_S.1
4QVQ_E.1
4QVQ_S.1
4QVV_E.1
4QVV_S.1
4QVW_E.1
4QVW_S.1
4QVY_E.1
4QVY_S.1
4QW0_E.1
4QW0_S.1
4QW1_E.1
4QW1_S.1
4QW3_E.1
4QW3_S.1
4QW4_E.1
4QW4_S.1
4QW5_E.1
4QW5_S.1
4QW6_E.1
4QW6_S.1
4QW7_E.1
4QW7_S.1
4QWF_E.1
4QWF_S.1
4QWG_E.1
4QWG_S.1
4QWI_E.1
4QWI_S.1
4QWJ_E.1
4QWJ_S.1
4QWK_E.1
4QWK_S.1
4QWL_E.1
4QWL_S.1
4QWR_E.1
4QWR_S.1
4QWS_E.1
4QWS_S.1
4QWU_E.1
4QWU_S.1
4QWX_E.1
4QWX_S.1
4QXJ_E.1
4QXJ_S.1
4QZ0_E.1
4QZ0_S.1
4QZ1_E.1
4QZ1_S.1
4QZ2_E.1
4QZ2_S.1
4QZ3_E.1
4QZ3_S.1
4QZ4_E.1
4QZ4_S.1
4QZ5_E.1
4QZ5_S.1
4QZ6_E.1
4QZ6_S.1
4QZ7_E.1
4QZ7_S.1
4QZW_E.1
4QZW_S.1
4QZX_E.1
4QZX_S.1
4QZZ_E.1
4QZZ_S.1
4R00_E.1
4R00_S.1
4R02_E.1
4R02_S.1
4R17_E.1
4R17_S.1
4R18_E.1
4R18_S.1
4RUR_E.1
4RUR_S.1
4X6Z_F.1
4X6Z_T.1
4Y69_E.1
4Y69_S.1
4Y6A_E.1
4Y6A_S.1
4Y6V_E.1
4Y6V_S.1
4Y6Z_E.1
4Y6Z_S.1
4Y70_E.1
4Y70_S.1
4Y74_E.1
4Y74_S.1
4Y75_E.1
4Y75_S.1
4Y77_E.1
4Y77_S.1
4Y78_E.1
4Y78_S.1
4Y7W_E.1
4Y7W_S.1
4Y7X_E.1
4Y7X_S.1
4Y7Y_E.1
4Y7Y_S.1
4Y80_E.1
4Y80_S.1
4Y81_E.1
4Y81_S.1
4Y82_E.1
4Y82_S.1
4Y84_E.1
4Y84_S.1
4Y8G_E.1
4Y8G_S.1
4Y8H_E.1
4Y8H_S.1
4Y8I_E.1
4Y8I_S.1
4Y8J_E.1
4Y8J_S.1
4Y8K_E.1
4Y8K_S.1
4Y8L_E.1
4Y8L_S.1
4Y8M_E.1
4Y8M_S.1
4Y8N_E.1
4Y8N_S.1
4Y8O_E.1
4Y8O_S.1
4Y8P_E.1
4Y8P_S.1
4Y8Q_E.1
4Y8Q_S.1
4Y8R_E.1
4Y8R_S.1
4Y8S_E.1
4Y8S_S.1
4Y8T_E.1
4Y8T_S.1
4Y8U_E.1
4Y8U_S.1
4Y9Y_E.1
4Y9Y_S.1
4Y9Z_E.1
4Y9Z_S.1
4YA0_E.1
4YA0_S.1
4YA1_E.1
4YA1_S.1
4YA2_E.1
4YA2_S.1
4YA3_E.1
4YA3_S.1
4YA4_E.1
4YA4_S.1
4YA5_E.1
4YA5_S.1
4YA7_E.1
4YA7_S.1
4YA9_E.1
4YA9_S.1
4Z1L_E.1
4Z1L_S.1
5BOU_E.1
5BOU_S.1
5BXL_E.1
5BXL_S.1
5BXN_E.1
5BXN_S.1
5CGF_E.1
5CGF_S.1
5CGG_E.1
5CGG_S.1
5CGH_E.1
5CGH_S.1
5CGI_E.1
5CGI_S.1
5CZ4_E.1
5CZ4_S.1
5CZ5_E.1
5CZ5_S.1
5CZ6_E.1
5CZ6_S.1
5CZ7_E.1
5CZ7_S.1
5CZ8_E.1
5CZ8_S.1
5CZ9_E.1
5CZ9_S.1
5CZA_E.1
5CZA_S.1
5D0S_E.1
5D0S_S.1
5D0T_E.1
5D0T_S.1
5D0V_E.1
5D0V_S.1
5D0W_E.1
5D0W_S.1
5D0X_E.1
5D0X_S.1
5D0Z_E.1
5D0Z_S.1
5DKI_E.1
5DKI_S.1
5DKJ_E.1
5DKJ_S.1
5FG7_E.1
5FG7_S.1
5FG9_E.1
5FG9_S.1
5FGA_E.1
5FGA_S.1
5FGD_E.1
5FGD_S.1
5FGE_E.1
5FGE_S.1
5FGF_E.1
5FGF_S.1
5FGG_E.1
5FGG_S.1
5FGH_E.1
5FGH_S.1
5FGI_E.1
5FGI_S.1
5FHS_E.1
5FHS_S.1
5JHR_E.1
5JHR_S.1
5JHS_E.1
5JHS_S.1
5L52_E.1
5L52_S.1
5L54_E.1
5L54_S.1
5L55_E.1
5L55_S.1
5L5A_E.1
5L5A_S.1
5L5B_E.1
5L5B_S.1
5L5D_E.1
5L5D_S.1
5L5E_E.1
5L5E_S.1
5L5F_E.1
5L5F_S.1
5L5H_E.1
5L5H_S.1
5L5I_E.1
5L5I_S.1
5L5J_E.1
5L5J_S.1
5L5O_E.1
5L5O_S.1
5L5P_E.1
5L5P_S.1
5L5Q_E.1
5L5Q_S.1
5L5R_E.1
5L5R_S.1
5L5S_E.1
5L5S_S.1
5L5T_E.1
5L5T_S.1
5L5U_E.1
5L5U_S.1
5L5V_E.1
5L5V_S.1
5L5W_E.1
5L5W_S.1
5L5X_E.1
5L5X_S.1
5L5Y_E.1
5L5Y_S.1
5L5Z_E.1
5L5Z_S.1
5L60_E.1
5L60_S.1
5L61_E.1
5L61_S.1
5L62_E.1
5L62_S.1
5L63_E.1
5L63_S.1
5L64_E.1
5L64_S.1
5L65_E.1
5L65_S.1
5L66_E.1
5L66_S.1
5L67_E.1
5L67_S.1
5L68_E.1
5L68_S.1
5L69_E.1
5L69_S.1
5L6A_E.1
5L6A_S.1
5L6B_E.1
5L6B_S.1
5L6C_E.1
5L6C_S.1
5LAI_E.1
5LAI_S.1
5LAJ_E.1
5LAJ_S.1
5LTT_E.1
5LTT_S.1
5M2B_E.1
5M2B_S.1
5MP9_F.1
5MP9_f.1
5MPA_F.1
5MPA_f.1
5MPB_F.1
5MPB_f.1
5MPC_F.1
5MPC_f.1
5NIF_F.1
5NIF_T.1
5WVI_F.1
5WVI_l.1
5WVK_F.1
5WVK_l.1
6EF0_F.1
6EF3_F.1
6G7F_E.1
6G7F_S.1
6G8M_E.1
6G8M_S.1
6G8N_E.1
6G8N_S.1
6GOP_E.1
6GOP_S.1
6H39_E.1
6H39_S.1
6HTB_E.1
6HTB_S.1
6HTC_E.1
6HTC_S.1
6HTD_E.1
6HTD_S.1
6HTP_E.1
6HTP_S.1
6HTR_E.1
6HTR_S.1
6HUB_E.1
6HUB_S.1
6HUC_E.1
6HUC_S.1
6HUQ_E.1
6HUQ_S.1
6HUU_E.1
6HUU_S.1
6HUV_E.1
6HUV_S.1
6HV3_E.1
6HV3_S.1
6HV4_E.1
6HV4_S.1
6HV5_E.1
6HV5_S.1
6HV7_E.1
6HV7_S.1
6HVA_E.1
6HVA_S.1
6HVR_E.1
6HVR_S.1
6HVS_E.1
6HVS_S.1
6HVT_E.1
6HVT_S.1
6HVU_E.1
6HVU_S.1
6HVV_E.1
6HVV_S.1
6HVW_E.1
6HVW_S.1
6HVX_E.1
6HVX_S.1
6HVY_E.1
6HVY_S.1
6HW0_E.1
6HW0_S.1
6HW3_E.1
6HW3_S.1
6HW4_E.1
6HW4_S.1
6HW5_E.1
6HW5_S.1
6HW6_E.1
6HW6_S.1
6HW7_E.1
6HW7_S.1
6HW8_E.1
6HW8_S.1
6HW9_E.1
6HW9_S.1
6HWA_E.1
6HWA_S.1
6HWB_E.1
6HWB_S.1
6HWC_E.1
6HWC_S.1
6HWD_E.1
6HWD_S.1
6HWE_E.1
6HWE_S.1
6HWF_E.1
6HWF_S.1
6J2C_F.1
6J2C_l.1
6J2N_F.1
6J2N_l.1
6J2Q_F.1
6J2Q_l.1
6J2X_F.1
6J2X_l.1
6J30_F.1
6J30_l.1
6ZOU_E.1
6ZOU_S.1
6ZP6_E.1
6ZP6_S.1
6ZP8_E.1
6ZP8_S.1
7LS5_F.1
7LS5_T.1
7LS6_F.1
7LSX_F.1
P40302.1