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    ERG8 phosphomevalonate kinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855260, updated on 11-Apr-2024

    Summary

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    Gene symbol
    ERG8
    Gene description
    phosphomevalonate kinase
    Primary source
    SGD:S000004833
    Locus tag
    YMR220W
    See related
    AllianceGenome:SGD:S000004833
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphomevalonate kinase activity. Involved in ergosterol biosynthetic process; organic acid phosphorylation; and phospholipid biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (712316..713671)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene transport protein particle complex II subunit TRS130 Neighboring gene Esc1p Neighboring gene Fmp42p Neighboring gene putative serine hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nonorthologous gene displacement of phosphomevalonate kinase. Houten SM, et al. Mol Genet Metab, 2001 Mar. PMID 11243736
    2. Cloning and characterization of ERG8, an essential gene of Saccharomyces cerevisiae that encodes phosphomevalonate kinase. Tsay YH, et al. Mol Cell Biol, 1991 Feb. PMID 1846667, Free PMC Article
    3. Targeted proteomics for metabolic pathway optimization: application to terpene production. Redding-Johanson AM, et al. Metab Eng, 2011 Mar. PMID 21215324
    4. A screening for essential cell growth-related genes involved in arsenite toxicity in Saccharomyces cerevisiae. Takahashi T, et al. J Toxicol Sci, 2011. PMID 22129753
    5. Linking genotype and phenotype of Saccharomyces cerevisiae strains reveals metabolic engineering targets and leads to triterpene hyper-producers. Madsen KM, et al. PLoS One, 2011 Mar 18. PMID 21445244, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphomevalonate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphomevalonate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphomevalonate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphomevalonate kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ergosterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ergosterol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ergosterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic acid phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in vacuole NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphomevalonate kinase
    NP_013947.1
    • Phosphomevalonate kinase; an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      712316..713671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182727.1 → NP_013947.1  TPA: phosphomevalonate kinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013947.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W045, P24521
      UniProtKB/TrEMBL
      A0A8H4BY17, B3LMA8, C8ZF84
      Conserved Domains (1) summary
      TIGR01219
      Location:6 → 447
      Pmev_kin_ERG8; phosphomevalonate kinase, ERG8-type, eukaryotic branch
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24521.2

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