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    RPL6A ribosomal 60S subunit protein L6A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854902, updated on 5-May-2024

    Summary

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    Gene symbol
    RPL6A
    Gene description
    ribosomal 60S subunit protein L6A
    Primary source
    SGD:S000004538
    Locus tag
    YML073C
    See related
    AllianceGenome:SGD:S000004538
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YL16A
    Summary
    Enables RNA binding activity. A structural constituent of ribosome. Involved in cytoplasmic translation and ribosomal large subunit assembly. Part of cytosolic large ribosomal subunit. Orthologous to human RPL6 (ribosomal protein L6). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XIII
    Exon count:
    2
    Sequence:
    Chromosome: XIII; NC_001145.3 (123227..124172, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 Neighboring gene peptidylprolyl isomerase FPR3 Neighboring gene Tcb3p Neighboring gene Golgi transport complex subunit COG8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein synthesis rates and ribosome occupancies reveal determinants of translation elongation rates. Riba A, et al. Proc Natl Acad Sci U S A, 2019 Jul 23. PMID 31292258, Free PMC Article
    2. Yeast ribosomal proteins: XIV. Complete nucleotide sequences of the two genes encoding Saccharomyces cerevisiae YL16. Hashimoto T, et al. Biochim Biophys Acta, 1992 Sep 24. PMID 1390890
    3. The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan. Mittal N, et al. Nat Commun, 2017 Sep 6. PMID 28878244, Free PMC Article
    4. Depletion of Saccharomyces cerevisiae ribosomal protein L16 causes a decrease in 60S ribosomal subunits and formation of half-mer polyribosomes. Rotenberg MO, et al. Genes Dev, 1988 Feb. PMID 3282992
    5. Proximity of 5.8 S RNA-binding proteins and A-site proteins in yeast ribosomes inferred from cross-linking. Lee JC, et al. J Biol Chem, 1984 Aug 25. PMID 6432786

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L6A
    NP_013638.1
    • Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      123227..124172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182432.1 → NP_013638.1  TPA: ribosomal 60S subunit protein L6A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013638.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZA0, Q02326
      UniProtKB/TrEMBL
      A6ZLZ2, B3LLI3, C8ZED2, G2WJY2, N1NXW3
      Conserved Domains (1) summary
      cd13156
      Location:26 → 176
      KOW_RPL6; KOW motif of Ribosomal Protein L6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    3JCT_E.1
    4V88_BE.1
    4V88_DE.1
    4V8T_E.1
    5APN_E.1
    5FL8_E.1
    5H4P_E.1
    5JCS_E.1
    5T62_H.1
    5T6R_H.1
    5Z3G_I.1
    6ELZ_E.1
    6EM1_E.1
    6EM3_E.1
    6EM4_E.1
    6EM5_E.1
    6FT6_E.1
    6M62_E.1
    6N8J_E.1
    6N8K_E.1
    6N8L_E.1
    6N8M_H.1
    6N8N_H.1
    6N8O_H.1
    7AZY_A.1
    7BT6_E.1
    7BTB_E.1
    7OF1_E.1
    7OH3_E.1
    7OHP_E.1
    7OHQ_E.1
    7OHR_E.1
    7OHS_E.1
    7OHT_E.1
    7OHU_E.1
    7OHV_E.1
    7OHW_E.1
    7OHX_E.1
    7OHY_E.1
    Q02326.2

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