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    CAC2 Cac2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854869, updated on 5-May-2024

    Summary

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    Gene symbol
    CAC2
    Gene description
    Cac2p
    Primary source
    SGD:S000004570
    Locus tag
    YML102W
    See related
    AllianceGenome:SGD:S000004570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to histone binding activity. Involved in DNA replication-dependent chromatin assembly. Located in chromosome, centromeric region; cytosol; and nucleus. Part of CAF-1 complex. Orthologous to human CHAF1B (chromatin assembly factor 1 subunit B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (68294..69700)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Nup188p Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Cue4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Cac2 subunit is essential for productive histone binding and nucleosome assembly in CAF-1. Mattiroli F, et al. Sci Rep, 2017 Apr 18. PMID 28418026, Free PMC Article
    2. Histone H3 N-terminal acetylation sites especially K14 are important for rDNA silencing and aging. Xu HH, et al. Sci Rep, 2016 Feb 24. PMID 26906758, Free PMC Article
    3. The CAF-1 and Hir Histone Chaperones Associate with Sites of Meiotic Double-Strand Breaks in Budding Yeast. Brachet E, et al. PLoS One, 2015. PMID 25938567, Free PMC Article
    4. Yeast ASF1 protein is required for cell cycle regulation of histone gene transcription. Sutton A, et al. Genetics, 2001 Jun. PMID 11404324, Free PMC Article
    5. Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I. Kaufman PD, et al. Genes Dev, 1997 Feb 1. PMID 9030687

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in DNA replication-dependent chromatin assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA replication-dependent chromatin assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication-dependent chromatin assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CAF-1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CAF-1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cac2p
    NP_013605.1
    • Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure, deactivation of the DNA damage checkpoint after DNA repair, chromatin dynamics during transcription; and repression of divergent transcription; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      68294..69700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182464.1 → NP_013605.1  TPA: Cac2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013605.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0I2, Q04199
      UniProtKB/TrEMBL
      A0A8H4BXH0, A6ZLW2, B3LLF6, N1P0G0
      Conserved Domains (2) summary
      sd00039
      Location:17 → 69
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:4 → 214
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04199.1

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