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    HOS4 Hos4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854694, updated on 4-Feb-2024

    Summary

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    Gene symbol
    HOS4
    Gene description
    Hos4p
    Primary source
    SGD:S000001374
    Locus tag
    YIL112W
    See related
    AllianceGenome:SGD:S000001374
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in histone deacetylation. Part of Set3 complex. Orthologous to human ANKHD1-EIF4EBP3 (ANKHD1-EIF4EBP3 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (151595..154846)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene putative porin POR2 Neighboring gene mitogen-activated protein kinase tyrosine protein phosphatase SDP1 Neighboring gene cytochrome c oxidase subunit Vb Neighboring gene protein-histidine N-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional analysis of the SET3 histone deacetylase complex. Reyes AA, et al. Acta Crystallogr F Struct Biol Commun, 2022 Mar 1. PMID 35234136, Free PMC Article
    2. Cyclophilin A is localized to the nucleus and controls meiosis in Saccharomyces cerevisiae. Arévalo-Rodríguez M, et al. Eukaryot Cell, 2005 Jan. PMID 15643056, Free PMC Article
    3. The Set3 Complex Antagonizes the MYST Acetyltransferase Esa1 in the DNA Damage Response. Torres-Machorro AL, et al. Mol Cell Biol, 2015 Nov. PMID 26303527, Free PMC Article
    4. Dimethylation of H3K4 by Set1 recruits the Set3 histone deacetylase complex to 5' transcribed regions. Kim T, et al. Cell, 2009 Apr 17. PMID 19379692, Free PMC Article
    5. Deciphering protein complexes and protein interaction networks by tandem affinity purification and mass spectrometry: analytical perspective. Shevchenko A, et al. Mol Cell Proteomics, 2002 Mar. PMID 12096120

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Set3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Hos4p
    NP_012154.1
    • Subunit of the Set3 complex; complex is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      151595..154846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179460.1 → NP_012154.1  TPA: Hos4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012154.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVH5, P40480
      UniProtKB/TrEMBL
      A0A8H4BZ30, N1P4E2
      Conserved Domains (2) summary
      sd00045
      Location:330 → 361
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:334 → 429
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40480.1

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