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    NRT1 nicotinamide riboside transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854237, updated on 27-Jan-2024

    Summary

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    Gene symbol
    NRT1
    Gene description
    nicotinamide riboside transporter
    Primary source
    SGD:S000005597
    Locus tag
    YOR071C
    See related
    AllianceGenome:SGD:S000005597
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    THI71; YOR29-22
    Summary
    Enables 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity and nicotinamide riboside transmembrane transporter activity. Involved in 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport; nicotinamide riboside transport; and thiamine transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (459480..461276, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Vam10p Neighboring gene sorting nexin 1 Neighboring gene GTPase-activating protein GYP1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tRNA-Pro

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a thiamin transport gene, THI10, from Saccharomyces cerevisiae. Enjo F, et al. J Biol Chem, 1997 Aug 1. PMID 9235906
    2. Nrt1 and Tna1-independent export of NAD+ precursor vitamins promotes NAD+ homeostasis and allows engineering of vitamin production. Belenky P, et al. PLoS One, 2011 May 11. PMID 21589930, Free PMC Article
    3. Saccharomyces cerevisiae YOR071C encodes the high affinity nicotinamide riboside transporter Nrt1. Belenky PA, et al. J Biol Chem, 2008 Mar 28. PMID 18258590
    4. Identification of yeast and human 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAr) transporters. Ceschin J, et al. J Biol Chem, 2014 Jun 13. PMID 24778186, Free PMC Article
    5. Characterization of Thi9, a novel thiamine (Vitamin B1) transporter from Schizosaccharomyces pombe. Vogl C, et al. J Biol Chem, 2008 Mar 21. PMID 18201975

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters, Thi7, Nrt1, and Thi72.
      Title: Yeast α-arrestin Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters.
    2. Nrt1-related molecules are conserved in particular fungi, suggesting a similar basis for nicotinamide riboside uptake
      Title: Saccharomyces cerevisiae YOR071C encodes the high affinity nicotinamide riboside transporter Nrt1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nicotinamide riboside transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables nicotinamide riboside transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nucleobase transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nicotinamide riboside transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nicotinamide riboside transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleobase transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thiamine transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nicotinamide riboside transporter
    NP_014714.1
    • High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; major transporter for 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine) uptake; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      459480..461276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183490.1 → NP_014714.1  TPA: nicotinamide riboside transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014714.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2D4, O00029, Q08485
      UniProtKB/TrEMBL
      A0A6V8RKT9, C8ZI32, G2WMU9
      Conserved Domains (1) summary
      cd11482
      Location:27 → 505
      SLC-NCS1sbd_NRT1-like; nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08485.1

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