SDH1 succinate dehydrogenase flavoprotein subunit SDH1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: SDH1
Gene description: succinate dehydrogenase flavoprotein subunit SDH1
Primary source: SGD:S000001631
Locus tag: YKL148C
See related: AllianceGenome:SGD:S000001631
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables flavin adenine dinucleotide binding activity and succinate dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, succinate to ubiquinone. Located in mitochondrial membrane. Part of mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone). Used to study several diseases, including Leigh disease; endocrine organ benign neoplasm (multiple); gastrointestinal stromal tumor; leukodystrophy; and mitochondrial complex II deficiency. Human ortholog(s) of this gene implicated in Leigh disease; dilated cardiomyopathy 1GG; lung non-small cell carcinoma; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHA (succinate dehydrogenase complex flavoprotein subunit A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (169207..171129, complement)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studies indicate that the flavinylation factor Sdh5 provided insight into the possible mechanism associated with Sdh1 flavinylation.
Title: Emerging concepts in the flavinylation of succinate dehydrogenase.
The NMR structure of Sdh5 represents the first eukaryotic structure of Pfam family PF03937 and reveals a conserved surface region, which likely represents a putative Sdh1-Sdh5 interaction interface.
Title: Solution NMR structure of yeast succinate dehydrogenase flavinylation factor Sdh5 reveals a putative Sdh1 binding site.
Sdh5 (originally named EMI5/YOL071W)is required for succinate dehydrogenase(SDH)-dependent respiration and for Sdh1 flavination
Title: SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.
A decrease in the amount of Sdh1p in the flx1Delta mutant strain has been determined to be due to a post-transcriptional control that involves regulatory sequences located upstream of the SDH1 coding sequence.
Title: Succinate dehydrogenase flavoprotein subunit expression in Saccharomyces cerevisiae--involvement of the mitochondrial FAD transporter, Flx1p.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables electron transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IDA Inferred from Direct Assay more info	PubMed
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
enables succinate dehydrogenase (quinone) activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate dehydrogenase (quinone) activity	IDA Inferred from Direct Assay more info	PubMed
enables succinate dehydrogenase (quinone) activity	IEA Inferred from Electronic Annotation more info
enables succinate dehydrogenase (quinone) activity	IGI Inferred from Genetic Interaction more info	PubMed
enables succinate dehydrogenase (quinone) activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular respiration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial electron transport, succinate to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, succinate to ubiquinone	IDA Inferred from Direct Assay more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
part_of mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: succinate dehydrogenase flavoprotein subunit SDH1

NP_012774.1

EC 1.3.5.1

Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits; mutations in human ortholog SDHA are associated with Leigh syndrome and predisposition to several cancers

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

169207..171129 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179714.1 → NP_012774.1 TPA: succinate dehydrogenase flavoprotein subunit SDH1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012774.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VX49, Q00711

UniProtKB/TrEMBL

A0A6A5PW50, A6ZZH4, B3LQV3, C7GSN6, G2WHP1, N1NZP2

Conserved Domains (1) summary

cl39091
Location:46 → 640

SdhA; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]